Results 61 to 70 of about 613,864 (293)

Inventors and gatekeepers?: The EU member states and the European external action service [PDF]

open access: yesJournal of Regional Security, 2016
This project reflects on the ambivalence of the EU member states in their relationships with the new institutional arm of European diplomacy - the European External Action Service, headed by the High Representative.
Sus Monika
doaj  

The Issue of Sovereignty in an Ever-Closer Union

open access: yesCroatian Yearbook of European Law and Policy, 2014
This paper aims to answer the following question: what is the understanding of the principle of sovereignty in the EU today, and how should this knowledge inform our actions tomorrow?
Tina Oršolić Dalessio
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

How to Develop Sustainable Public Administration Reforms

open access: yesTransylvanian Review of Administrative Sciences, 2015
Public administration reform and reform in general is a never ending story. The human so-cieties are evolving and so do their needs. Pub-lic administration has to keep the pace with the changes that are taking place in society. Specifc issues like ageing
Liviu RADU
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

DETERMINANTS OF INTRA-INDUSTRY TRADE OF THE NEW MEMBER STATES [PDF]

open access: yesJournal of Economic and Social Development (Varaždin), 2016
The paper aims to analyze the determinants of intra-industry trade (IIT = simultaneous export and import of similar goods produced in one industry) of the New Member States (NMS defined as 14 countries accessing the EU in the years 2004 and 2007). In our
Katarzyna Sledziewska, E. Czarny
doaj  

Creación de una Guardia Europea de Fronteras y Costas: Breve análisis de la propuesta de Reglamento de la Comisión Europea de 15 de diciembre de 2015

open access: yesEuropean Papers, 2016
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(1), 203-212 | European Forum Insight of 16 April 2016 | (Table of Contents) I. Introducción. - II. El germen de la Guardia Europea de Fronteras y Costas. - III.
David Fernández Rojo
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

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