Results 151 to 160 of about 10,826,789 (331)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
PREDICTION OF AIRCRAFT NORMAL OVERLOAD EXTREME VALUE BASED ON PEARSON-Ⅲ DISTRIBUTION
Jixie qiangdu, 2018 Based on Pearson-Ⅲ distribution（ P-Ⅲ） representing much capacity for fitting extreme value data,research on Nzextreme values were carried on. Calculation method on the deviation coefficients Φp of skew coefficients Cswas deduced and established,which ...
LEI XiaoBo +3 more
doaj
Smart Fall Detection by Enhanced SVM with Fuzzy Logic Membership Function
, 2023 Mohammad Kchouri +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Design Evaluation of Learning Type Fuzzy Inference Using Trapezoidal Membership Function
, 2019 Honoka Irie, Isao Hayashi
openalex +2 more sources
Fuzzy BCI‐subalgebras with interval‐valued membership functions [PDF]
, 2001 Sung Min Hong +3 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Automatic Generation of Fuzzy Membership Functions using Adaptive Mean-shift and Robust Statistics
, 2016 Hossein Pazhoumand-Dar +2 more
openalex +1 more source