Results 111 to 120 of about 765,979 (297)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Additional Smoothing Transition Autoregressive Models [PDF]

open access: yes
In this paper we present, propose and examine additional membership functions. There is no reason why more functions cannot be proposed. More specifically, we present the tangent hyperbolic, Gaussian and Generalized bell functions.
Giovanis, Eleftherios
core   +1 more source

Identifying Finite-Time Coherent Sets from Limited Quantities of Lagrangian Data

open access: yes, 2015
A data-driven procedure for identifying the dominant transport barriers in a time-varying flow from limited quantities of Lagrangian data is presented. Our approach partitions state space into pairs of coherent sets, which are sets of initial conditions ...
Rowley, Clarence W.   +2 more
core   +1 more source

Analisis Perbandingan Single Membership Function dan Double Membership Function pada Diagnosis Penyakit ISPA

open access: yesJurnal Edukasi dan Penelitian Informatika (JEPIN)
Penyakit ISPA (Infeksi Saluran Pernafasan Akut) merupakan penyakit yang dapat menular. Penyakit ini disebabkan karena terjadinya infeksi dari bakteri maupun virus yang sering terjadi setiap tahunnya. Dalam keseharian, terkadang kita tidak dapat menyatakan sesuatu sebagai benar atau salah, namun kita harus menyatakannya dalam pernyataan hampir benar ...
Muhammad Fikri Hanif   +2 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Decision-maker’s behavioral preferences modeling in fuzzy goal programming through linear-nonlinear membership functions

open access: yesResults in Control and Optimization
A relevant extension of traditional goal programming (GP), fuzzy goal programming (FGP) can handle uncertainty and imprecision in multi-objective optimization problems.
Mohamed Sadok Cherif
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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