Results 181 to 190 of about 49,970 (201)

Organizational models for acute gastrointestinal bleeding: a systematic review of hospital networks, multidisciplinary care and bloodless programs (2015-2025). [PDF]

Front Med (Lausanne)
Otegen S, Yermukhanova LS, Baimakhanov A, Ashuri N, Muratkyzy AO, Zhylgeldy AA, Jakanov M, Arynova G, Afshar A.   +8 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Dmax-derived lactate-threshold intensity profiles and associated factors in adolescent swimmers: a multicenter cross-sectional study. [PDF]

Front Physiol
Lyu J, Liu G, Li J, Lei L, Zhang Z, Gao J.   +5 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Improving Laboratory Continuous Professional Development Training in Africa: The ASLM Academy Experience. [PDF]

Trop Med Int Health
Ndlovu N, Erasmus RT, Mashate S, Waweru MM, Zemlin AE.   +4 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Aim high, stay private: differentially private synthetic data enables public release of behavioral health information with high utility. [PDF]

JAMIA Open
Ghasemizade M, Lovato J, Danforth C, Dodds PS, Bloomfield LSP, Price M, Near J.   +6 more
europepmc   +1 more source

Beyond speed and strategy: A configurational analysis of collective attention to post-match institutional discourse in the UEFA Champions League. [PDF]

PLoS One
Ling Z, Ren X, Luo B.
europepmc   +1 more source

Towards reproducible multimorbidity clustering in electronic health records: a transparent pipeline for aligning research aims and methodology

Moreno GR, Restocchi V, De Ferrari L, Palmer J, Fleuriot J, Guthrie B, Lone N.   +6 more
europepmc   +1 more source

High AUROC can mask decision failure in sepsis transcriptomic classifiers: Preprocessing stability outweighs post hoc calibration across cohorts. [PDF]

PLoS One
Zheng H, Chen W.
europepmc   +1 more source