Results 51 to 60 of about 49,970 (201)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A GIS-Assisted Fuzzy Approach to Geographical Clustering of Mobile Phone Users’ Travel Behavior

Geomatics
Mobile phone usage data inherently involve many spatial elements; therefore, gathering extensive individual mobile phone records can offer unique insights into human spatial behavior at both personal and societal levels.
Ákos Jakobi, Márton Prorok, Tünde Szabó   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Czech political candidate and donation datasets

Scientific Data
This paper introduces a new Czech Political Candidate Dataset (CPCD), which compiles comprehensive data on all candidates who have run in any municipal, regional, national, and/or European Parliament election in the Czech Republic since 1993.
Lukáš Linek, Michael Škvrňák, Michal Šoltés, Vítězslav Titl   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A Gaia DR3 Core-membership Catalog for 359 Open Clusters from M-CTNC

The Astrophysical Journal Supplement Series
We release a Gaia DR3 astrometric core-membership catalog for 359 benchmark open clusters. The principal CORE _ BENCHMARK product contains 15,875 source entries from fixed local fields and uses only sky position, parallax, and proper motion; Gaia ...
Hao Wang, Luosheng Wen
doaj   +1 more source

Factors influencing the performance of clinical research networks to improve the success of cancer clinical trials: A scoping review and organizational analysis

Journal of Clinical and Translational Science
Cancer clinical research networks (CRNs) play a vital role in medical research globally by generating investigator-initiated research, pooling expertise, and enabling recruitment across multiple sites. Completing clinical trials is challenging.
Elizabeth Jane Paton, Tim Luckett, Gerald Blaise Fogarty, Anthony Greville Shannon, Deborah Debono   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A novel approach towards web browser using the concept of a complex spherical fuzzy soft information

Scientific Reports
The modern technology is the practical application of scientific knowledge, whether in industry or daily life, for goals or purposes. More quickly than any other technological advancement in human history, digital technologies have advanced.
Wenkai Shao, Shoukat Hussain, Sami Ullah Khan, Fuad A. Awwad, Emad A. A. Ismail   +4 more
doaj   +1 more source