Results 141 to 150 of about 4,320,334 (318)

Disruption of the PIKfyve complex unveils an adaptive mechanism to promote lysosomal repair and mitochondrial homeostasis

Nature Communications
Lysosomes are essential organelles that regulate cellular homeostasis through complex membrane interactions. Phosphoinositide lipids play critical roles in orchestrating these functions by recruiting specific proteins to organelle membranes.
Candice Kutchukian, Maria Casas, Rose E. Dixon, Eamonn J. Dickson   +3 more
doaj   +1 more source

CARGILE MEMBRANE

Annals of Surgery, 1905
n ...
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact of the surface energy of particulate foulants on membrane fouling

, 2016
Foulant-foulant and foulant-membrane interfacial interactions play an important role in dictating the extent of fouling. In order to understand the impact of the surface energy of particulate foulants on the fouling extent, the direct observation through
Cornelissen, Emile R., Fane, Anthony G., Ullah, Asmat, Chew, Jia Wei, Fane, Anthony Gordon, Akhondi, Ebrahim, Honciuc, Andrei, Tanudjaja, Henry Jonathan, Tanudjaja, Henry J., Zamani, Farhad, Cornelissen, Emile, Fane, Anthony G, Tanudjaja, Henry J   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Topological quantum materials for spintronics

MetalMat
Spintronics is an innovative field that exploits the intrinsic spin property of electrons instead of their charge, holding the promise of revolutionizing conventional electronic devices.
Jinyu Duan, Shuai Hu, Ping Wang, Delin Zhang, Yong Jiang   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Development of low mass-transfer-resistance fluorinated TiO2-SiO2/PVDF composite hollow fiber membrane used for biogas upgrading in gas-liquid membrane contactor

, 2018
An inorganic-organic fluorinated titania-silica (fTiO2-SiO2)/polyvinylidene fluoride (PVDF) composite membrane was fabricated, via facile in-situ vapor-induced hydrolyzation method followed by hydrophobic modification.
Yilin Xu, Chandresh Malde, Xu, Yilin, Melanie Lee, Rong Wang, Wang, Rong, Malde, Chandresh, Yuqing Lin, Lin, Yuqing, Lee, Melanie   +9 more
core   +1 more source

Electrochemical reactor with carbon membrane electrodes for efficient phenol removal via anode and cathode synergism

npj Clean Water
Current electrochemical membrane reactors (EMRs) focus on half-cell reactions, which limits their efficiency. Herein, an EMR-P with full-cell reactions was constructed using a carbon membrane (CM) as the cathode and a TiO2-loaded CM as the anode ...
Zishang Chen, Hong Wang, Yuxuan Zhu, Xiaoping Chen, Shuanglin Gui, Aijing Ma, Jianxin Li   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source