Results 211 to 220 of about 2,200,142 (368)

Role of eIF4A1 in triple‐negative breast cancer stem‐like cell‐mediated drug resistance

open access: yesCancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract In cap‐dependent translation, the eukaryotic translation initiation factor 4A (eIF4A1) is an mRNA helicase is involved in unwinding of the secondary structure, such as the stem‐loops, at the 5′‐leader regions of the key oncogenic mRNAs. This facilitates ribosomal scanning and translation of the oncogenic mRNAs.
Dayanidhi Raman, Amit K. Tiwari
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

open access: yesAngewandte Chemie, EarlyView.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song   +8 more
wiley   +2 more sources

Antiviral effects and mechanism of Qi pi pill against influenza viruses

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang   +10 more
wiley   +1 more source

Automated fluorescence gating and size determination reduce variation in measured concentration of extracellular vesicles by flow cytometry

open access: yesCytometry Part A, Volume 101, Issue 12, Page 1049-1056, December 2022., 2022
Abstract Extracellular vesicles (EVs) are an upcoming biomarker for disease. However, the measured concentrations of EVs by flow cytometry are incomparable due to analytical variables. This study aimed to investigate how the choice of fluorophore, and thereby brightness, affects the measured concentration of EVs.
Angela Adriana Francisca Gankema   +3 more
wiley   +1 more source

Identification of bioactive compounds and molecular targets of Fuke Huahuang formulation to treat vaginitis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu   +5 more
wiley   +1 more source

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