Results 1 to 10 of about 205,984 (95)

Effects of membrane potentials on the electroporation of giant unilamellar vesicles. [PDF]

PLoS ONE, 2023
Living organisms maintain a resting membrane potential, which plays an important role in various biophysical and biological processes. In the context of medical applications, irreversible electroporation (IRE) is a non-thermal and minimally invasive ...
Md Abdul Wadud, Mohammad Abu Sayem Karal, Md Moniruzzaman, Md Mamun Or Rashid   +3 more
doaj   +2 more sources

Synaptic NMDA receptor activity at resting membrane potentials [PDF]

Frontiers in Cellular Neuroscience, 2022
NMDA receptors (NMDARs) are crucial for glutamatergic synaptic signaling in the mammalian central nervous system. When activated by glutamate and glycine/D-serine, the NMDAR ion channel can open, but current flux is further regulated by voltage-dependent
Delia N. Chiu, Brett C. Carter
doaj   +2 more sources

Membrane water for probing neuronal membrane potentials and ionic fluxes at the single cell level [PDF]

Nature Communications, 2018
Non-invasive spatiotemporal probing of electric potentials in living neurons without chemical or genetic modification provides a major advancement to neuroscience.
M. E. P. Didier, O. B. Tarun, P. Jourdain, P. Magistretti, S. Roke   +4 more
doaj   +2 more sources

Membrane potential modulates ERK activity and cell proliferation in human cells [PDF]

eLife
Plasma membrane potential has been linked to cell proliferation for over 40 years in vertebrate cells. In this study, we experimentally demonstrated that membrane depolarization promotes mitosis and that this process depends on the voltage-dependent ...
Mari Sasaki, Masanobu Nakahara, Takuya Hashiguchi, Fumihito Ono   +3 more
doaj   +2 more sources

Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels. [PDF]

PLoS Biology
Fast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders.
Léa Demesmay, Romane Idoux, Christine Berthier, Claire Bernat, Léon Espinosa, Vincent Jacquemond, Frédéric Brunet, Angel Maunier-Mercier, Philippe Lory, Sophie Nicole, Bruno Allard   +10 more
doaj   +2 more sources

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells

Cells, 2023
Optical mapping is a powerful imaging technique widely adopted to measure membrane potential changes and intracellular Ca2+ variations in excitable tissues using voltage-sensitive dyes and Ca2+ indicators, respectively.
Mohammed Djemai, Michael Cupelli, Mohamed Boutjdir, Mohamed Chahine   +3 more
doaj   +1 more source

Positively charged mineral surfaces promoted the accumulation of organic intermediates at the origin of metabolism.

PLoS Computational Biology, 2022
Identifying plausible mechanisms for compartmentalization and accumulation of the organic intermediates of early metabolic cycles in primitive cells has been a major challenge in theories of life's origins.
Amir Akbari, Bernhard O Palsson
doaj   +1 more source

On the accuracy of cell-attached current-clamp recordings from cortical neurons

Frontiers in Molecular Neuroscience, 2022
Cell-attached current-clamp (CA/CC) recordings have been proposed to measure resting membrane potential and synaptic/agonist responses in neurons without disrupting the cell membrane, thus avoiding the intracellular dialysis that occurs in conventional ...
Alina Vazetdinova, Fliza Valiullina-Rakhmatullina, Andrei Rozov, Andrei Rozov, Andrei Rozov, Alexander Evstifeev, Roustem Khazipov, Roustem Khazipov, Azat Nasretdinov   +8 more
doaj   +1 more source

BRANEart: Identify Stability Strength and Weakness Regions in Membrane Proteins

Frontiers in Bioinformatics, 2021
Understanding the role of stability strengths and weaknesses in proteins is a key objective for rationalizing their dynamical and functional properties such as conformational changes, catalytic activity, and protein-protein and protein-ligand ...
Sankar Basu, Sankar Basu, Simon S. Assaf, Fabian Teheux, Marianne Rooman, Marianne Rooman, Fabrizio Pucci, Fabrizio Pucci   +7 more
doaj   +1 more source

Taste Receptor Cells Generate Oscillating Receptor Potentials by Activating G Protein-Coupled Taste Receptors

Frontiers in Physiology, 2022
The receptor potentials of taste receptor cells remain unclear. Here, we demonstrate that taste receptor cells generate oscillating depolarization (n = 7) with action potentials in response to sweet, bitter, umami, and salty taste substances.
Yoshiki Nakao, Katsumi Tateno, Yoshitaka Ohtubo   +2 more
doaj   +1 more source