Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (If) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases.
Y. Yaniv+4 more
semanticscholar +1 more source
Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri+36 more
core +1 more source
The membrane potential of human platelets [PDF]
Abstract The membrane potential of the human platelet was investigated using the membrane potential probes 3,3′-dipropyl-2,2′-thiadicarbocyanine iodide and tritiated triphenylmethylphosphonium bromide. The membrane potential in physiologic buffer was estimated to be 52–60 mV inside negative.
Martin Sonenberg, Lawrence T. Friedhoff
openaire +4 more sources
On the physiological and cellular homeostasis of ascorbate
Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well-being and recovery from a variety of medical
Magdalena Przybyło, Marek Langner
doaj +1 more source
Different Roles of Membrane Potentials in Electrotaxis and Chemotaxis of Dictyostelium Cells
Many types of cells migrate directionally in direct current (DC) electric fields (EFs), a phenomenon termed galvanotaxis or electrotaxis. The directional sensing mechanisms responsible for this response to EFs, however, remain unknown.
Runchi Gao+6 more
semanticscholar +1 more source
Excitatory postsynaptic potentials in rat neocortical neurons in vitro. III. Effects of a quinoxalinedione non-NMDA receptor antagonist [PDF]
1. Intracellular microelectrodes were used to obtain recordings from neurons in layer II/III of rat frontal cortex. A bipolar electrode positioned in layer IV of the neocortex was used to evoke postsynaptic potentials.
Hablitz, John H., Sutor, Bernd
core +1 more source
Motoneuron membrane potentials follow a time inhomogeneous jump diffusion process
Stochastic leaky integrate-and-fire models are popular due to their simplicity and statistical tractability. They have been widely applied to gain understanding of the underlying mechanisms for spike timing in neurons, and have served as building blocks ...
P. Jahn+3 more
semanticscholar +1 more source
Elastic moderation of intrinsically applied tension in lipid membranes [PDF]
Tension in lipid membranes is often controlled externally, by pulling on the boundary of the membrane or changing osmotic pressure across a curved membrane. But modifications of the tension can also be induced in an internal fashion, for instance as a byproduct of changing a membranes electric potential or, as observed experimentally, by activity of ...
arxiv +1 more source
Optogenetic monitoring of membrane potentials
Over the last decade, researchers in our laboratory have engineered and developed several series of genetically encoded voltage‐sensitive fluorescent proteins (VSFPs) by molecular fusion of a voltage‐sensing domain operand with different fluorescent ...
H. Mutoh+4 more
semanticscholar +1 more source
A space-fractional cable equation for the propagation of action potentials in myelinated neurons [PDF]
Myelinated neurons are characterized by the presence of myelin, a multilaminated wrapping around the axons formed by specialized neuroglial cells. Myelin acts as an electrical insulator and therefore, in myelinated neurons, the action potentials do not ...
Drapaca, Corina S.+2 more
core +2 more sources