Results 111 to 120 of about 1,865,200 (318)
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Studies on Electrophoresis on Cellulose Acetate Membrane of Bovine Serum Proteins in Healthy Animals [PDF]
, 1969 Nils Ek
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Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Rational design of chemical- and light-inducible cGAS activation based on mechanistic insights
Communications BiologyCyclic GMP-AMP synthase (cGAS) plays a pivotal role in the cGAS-STING pathway as a DNA sensor that binds to double-stranded DNA (dsDNA) and subsequently induces type I interferon expression, thereby contributing significantly to the innate immune ...
Yiting Tang, Wenjuan Wang, Chunlai Chen
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Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
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A MUTATION WHICH CHANGES A MEMBRANE PROTEIN OF E. coli
, 1969 Masayori Inouye, J. Peter Guthrie
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
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Fractionation of the Protein Components of Human Erythrocyte Membranes
, 1969 Steven A. Rosenberg, Guido Guidotti
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Effect of streptolysin O on erythrocyte membranes, liposomes, and lipid dispersions. A protein-cholesterol interaction. [PDF]
, 1975 J L Duncan, Robert Schlegel
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