Results 121 to 130 of about 9,896,950 (388)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Regulation of Leukocytes by TspanC8 Tetraspanins and the “Molecular Scissor” ADAM10

Frontiers in Immunology, 2018
A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane protein that functions as a “molecular scissor” to cleave the extracellular regions from its transmembrane target proteins. ADAM10 is well characterized as the ligand-dependent
Alexandra L. Matthews, Chek Ziu Koo, Chek Ziu Koo, Justyna Szyroka, Neale Harrison, Aditi Kanhere, Michael G. Tomlinson, Michael G. Tomlinson   +7 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Half a century after their discovery: Structural insights into exonuclease and annealase proteins catalyzing recombineering

Engineering Microbiology
Recombineering is an essential tool for molecular biologists, allowing for the facile and efficient manipulation of bacterial genomes directly in cells without the need for costly and laborious in vitro manipulations involving restriction enzymes.
Lucy J. Fitschen, Timothy P. Newing, Nikolas P. Johnston, Charles E. Bell, Gökhan Tolun   +4 more
doaj   +1 more source

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins [PDF]

, 2010
Athanasios Typas, Manuel Banzhaf, H. Bart van den Berg van Saparoea, Jolanda Verheul, Jacob Biboy, Robert J. Nichols, Matylda Zietek, Katrin Beilharz, Kai Kannenberg, Moritz von Rechenberg, Eefjan Breukink, Tanneke den Blaauwen, Carol A. Gross, Waldemar Vollmer   +13 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A reference dataset for the analyses of membrane protein secondary structures and transmembrane residuesusing circular dichroism spectroscopy [PDF]

, 2011
Ali Abdul-Gader, Andrew J. Miles, B.A. Wallace   +2 more
openalex   +1 more source

Predicting the Structure and Dynamics of Membrane Protein GerAB from Bacillus subtilis [PDF]

, 2021
Sophie Blinker, Jocelyne Vreede, Peter Setlow, Stanley Brul   +3 more
openalex   +1 more source