Results 251 to 260 of about 1,504,627 (332)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease. [PDF]

Int J Mol Sci
Kon T, Lee S, Martinez-Valbuena I, Yoshida K, Tanikawa S, Lang AE, Kovacs GG.   +6 more
europepmc   +1 more source

Study Of The Transport Of Multivalent Metal Cations Through Cation-Exchange Membranes By Electrochemical Impedance Spectroscopy

, 2015
V. Pérez‐Herranz, M. Pinel, E. Ortega, M. García-Gabaldón   +3 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A kinetic mechanism for enhanced selectivity of membrane transport. [PDF]

PLoS Comput Biol, 2020
Bisignano P, Lee MA, George A, Zuckerman DM, Grabe M, Rosenberg JM.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Discovery and structural characterization of the D-box, a conserved TonB motif that couples an inner-membrane motor to outer-membrane transport. [PDF]

J Biol Chem
Loll PJ, Grasty KC, Shultis DD, Guzman NJ, Wiener MC.   +4 more
europepmc   +1 more source

Terahertz Time-Domain Spectroscopy Insights into Ionic Transport and Hydration Stability of Dual- Functionalised Nafion Membranes [PDF]

Abhishek B., Jayarama Krishna A., Snehal Haldankar, Deekshitha K, Shashi Kumar Kumaraswamy, Amit Shah, Sriganesh S. Prabhu, Satyanarayan, Ananda Kumar M G, R. Pinto   +9 more
openalex   +1 more source

Na+/Ca2+ Exchange, Ca2+ Binding, and Electrogenic Ca2+ Transport in Plasma Membranes of Human Placental Syncytiotrophoblast [PDF]

, 1994
Siddharth G. Kamath, Carl H. Smith
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source