Results 101 to 110 of about 176 (175)
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, EarlyView.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
Differential contribution of canonical and non-canonical NLGN3 pathways to early social development and memory performancesArticle 富山大学・富生命博甲第160号・李 林煜・2024/03/22・★論文非公開★
openaire +2 more sources
Cancer Science, EarlyView.Schematic illustration showing how CRC‐associated ADSC‐derived CCL8 promotes colorectal cancer cell migration through ERK/HIF‐1α signaling in a 3D coculture platform. ABSTRACT This study aimed to recapitulate adipose‐tumor interactions within the colorectal cancer (CRC) tumor microenvironment (TME) and to elucidate the role of adipose‐derived stem ...
Jeong‐Eun Yun +7 more
wiley +1 more source
Stochastic Pairwise MIS for Unbiased Large‐Kernel Reuse in Real‐Time
Computer Graphics Forum, EarlyView.Abstract Spatiotemporal resampling methods such as ReSTIR decrease noise in Monte Carlo rendering of dynamic content by reusing paths across frames and pixels. Standard ReSTIR reuses spatially from a small number of randomly selected neighbors. This reuse suffers when few neighbors contain contributing samples, reducing quality toward that of the ...
Trevor Hedstrom +4 more
wiley +1 more source
The Story(line) So Far: A Survey on Storyline Visualization
Computer Graphics Forum, EarlyView.Abstract Storyline visualizations model narratives as temporal networks, using x‐monotone lines to represent entities and their interactions over time. This technique offers an intuitive way to reveal structural patterns over time, such as character co‐occurrence and narrative flow.
S. Di Bartolomeo +4 more
wiley +1 more source
Cell Proliferation, EarlyView.This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo +5 more
wiley +1 more source
The Pan‐Orthodox Celebration of the 1600th Anniversary of the Council of Nicaea in 1925
The Ecumenical Review, EarlyView.Abstract This article explores the attempts to organize a Pan‐Orthodox Council in the years following the First World War that could gather in 1925 on the occasion of the 1600th anniversary of the First Ecumenical Council of Nicaea. While some of these efforts were remarkably ambitious, and although they were not always feasible or fully realized, they
Natallia Vasilevich
wiley +1 more source
Defrosting humanism: Losing my ethical worldview in the wake of October 7th and Israel's retaliation
Ethos, EarlyView.Abstract This auto‐ethnographic analysis describes the loss of my ethical worldview and my attempts to regain it following the October 7th Hamas attack on Israel and the subsequent Israeli retaliation. On October 7th, I was unable to feel compassion for the people of Gaza or to take action against the Israeli retaliation, aspects that I used to see as ...
Yael Assor
wiley +1 more source
Melusine, Emblem of the Self: The Female Traveler and the Contours of Acceptable Difference
The German Quarterly, EarlyView.Abstract Though the foreign roots of Volksbücher such as Thüring von Ringoltingen's Melusine (1457) have long been recognized, these early modern German prose novels are still characterized as insular and folksy. Taking Melusine as an example, this article uses the framework of mobility to offer a new interpretation that posits the Volksbuch as an ...
Andrew C. Sternhagen Schwenk
wiley +1 more source