Results 21 to 30 of about 176 (175)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

"Circassian" narratives in modern politics of memory in Georgia (2011–2021)

Кавказология
This study analyzes the Circassian dimension in the modern Georgian politics of memory. The author analyzes the main vectors and trajectories of the development of Circassian narratives in the modern memorial canon of Georgia.
M. V. Kirchanov
doaj   +1 more source

Fully automatic fossa ovalis segmentation from computed tomography images using deep neural network with atlas-based localization

Informatics in Medicine Unlocked
Background and objective: Information on the location of the fossa ovalis (FO) is necessary for planning interventional procedures that require an inter-atrial septal (IAS) puncture.
Gakuto Aoyama, Toru Tanaka, Yukiteru Masuda, Naoki Matsuki, Ryo Ishikawa, Masahiko Asami, Kiyohide Satoh, Takuya Sakaguchi   +7 more
doaj   +1 more source

Assessing Agreement and Variability Among Alternative Devices for Intraocular Pressure Measurement: A Comparative Study

Clinical Ophthalmology, 2023
Chen-Wei Lin,1,2,* Jin-Jhe Wang,2,* Chien-Hsiung Lai,2– 5 Chau-Yin Chen,2,3 Ing-Chou Lai2,3,6 1Department of Medical Education, Chang Gung Memorial Hospital, Chiayi, 61363, Taiwan; 2Department of Ophthalmology, Chang Gung Memorial Hospital ...
Lin CW, Wang JJ, Lai CH, Chen CY, Lai IC
doaj  

Hugo Kołłątaj, a State Prisoner in Olomouc a Josefov in 1794–1802

Poznańskie Studia Slawistyczne, 2018
The Kraków canon priest Hugo Kołłątaj (1750–1812), one of the authors of the Polish Constitution of 3rd May 1791, a writer, philosopher and teacher, the rector of the Jagiellonian University and the Vice-Chancellor of the Polish-Lithuanian Union ...
Marie Sobotková
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Genesis and Metamorphoses of the Soviet Ritual Canon of Commemoration of the Dead Participants of the Great Patriotic War (1940s–1960s)

Известия Уральского федерального университета. Серия 2: Гуманитарные науки
This article examines the emergence and subsequent development of ritual and memorial practices related to the commemoration of the dead participants in the Great Patriotic War in the USSR in the 1940s–1960s.
Aleksei Dmitrievich Popov
doaj   +1 more source

Omaeluloolisus nullindatel / Estonian Life Writing of the 2000s as a Continuity Over the Post-Soviet Period

Methis: Studia Humaniora Estonica, 2013
A distinctive feature of the (literary) culture of the 2000s is a sudden increase in the publication of works of life writing in different genres. Although life writing as a phenomenon has received considerably more critical attention in recent years, it
Leena Kurvet-Käosaar, Rutt Hinrikus
doaj   +1 more source