Results 81 to 90 of about 489,084 (307)

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Research by design: honouring the Stolen Generation a theoretical anti-memorial

open access: yesLandscape Review, 1999
This paper discusses theoretical design frameworks and research methods for contemporary memorial design. It is a case study for research by design, an expanding area of design discourse, which offers an alternative to quantitative research practices and
Sue-Anne Ware
doaj  

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

open access: yesArthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg   +20 more
wiley   +1 more source

Cognitive Behavioral Therapy for Youth with Childhood‐Onset Lupus: A Randomized Clinical Trial

open access: yesArthritis Care &Research, Accepted Article.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham   +29 more
wiley   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo   +7 more
wiley   +1 more source

Genesis and Metamorphoses of the Soviet Ritual Canon of Commemoration of the Dead Participants of the Great Patriotic War (1940s–1960s)

open access: yesИзвестия Уральского федерального университета. Серия 2: Гуманитарные науки
This article examines the emergence and subsequent development of ritual and memorial practices related to the commemoration of the dead participants in the Great Patriotic War in the USSR in the 1940s–1960s.
Aleksei Dmitrievich Popov
doaj   +1 more source

Memorial Healthcare System: A Public System Focusing on Patient- and Family-Centered Care [PDF]

open access: yes, 2010
Outlines a successful multifaceted strategy that includes personalizing healthcare quality, monitoring and reporting of performance data, careful design of care processes, and the system's vertical and horizontal integration.
Jennifer N. Edwards
core  

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

open access: yesAdvanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi   +7 more
wiley   +1 more source

Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

open access: yesInfection and Drug Resistance, 2023
Hanwen Cheng,1,* Haoyu Wu,1,* Ni Tan,2,* Zhuojie Liu,1 Ning Wang,1 Ningyi Chen,1 Chunhai Li1,3 1Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, People’s Republic of China ...
Cheng H   +6 more
doaj  

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

open access: yesAdvanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao   +20 more
wiley   +1 more source

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