Results 81 to 90 of about 110,606 (306)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang   +15 more
wiley   +1 more source

Rapid visualization of latent fingermarks using gold seed-mediated enhancement

open access: yesJournal of Nanobiotechnology, 2016
Background Fingermarks are one of the most important and useful forms of physical evidence in forensic investigations. However, latent fingermarks are not directly visible, but can be visualized due to the presence of other residues (such as inorganic ...
Chia-Hao Su   +2 more
doaj   +1 more source

Sociology 4120 : sociology of culture. Lecture 19. Western church architecture. Part 02

open access: yes, 1984
Sociology 4120: Sociology of Culture with Prof. Clinton S. Herrick studies art, in every form, and its relationship to human society.
Memorial University of Newfoundland. Educational Television Centre; Herrick, Clinton S.
core  

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

open access: yesAdvanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li   +13 more
wiley   +1 more source

Research by design: honouring the Stolen Generation a theoretical anti-memorial

open access: yesLandscape Review, 1999
This paper discusses theoretical design frameworks and research methods for contemporary memorial design. It is a case study for research by design, an expanding area of design discourse, which offers an alternative to quantitative research practices and
Sue-Anne Ware
doaj  

Sociology 4120 : sociology of culture. Lecture 16. Modern and Post-Modern architecture

open access: yes, 1984
Sociology 4120: Sociology of Culture with Prof. Clinton S. Herrick studies art, in every form, and its relationship to human society.
Memorial University of Newfoundland. Educational Television Centre; Herrick, Clinton S.
core  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

open access: yesAdvanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li   +15 more
wiley   +1 more source

Semiotic Analysis of the Symbolic World of the Culture Complex

open access: yesSpace and Culture, India, 2019
This research probes the symbolic meaning of the Korkyt Ata Complex aimed at understanding the cultural and spiritual life of the ancient Turkic people. Perhaps, this is the first instance when the semiotic analysis technique has been applied to studying
Zharkynbek Abikenov   +4 more
doaj   +1 more source

Sociology 4120 : sociology of culture. Lecture 25. Art as an occupation

open access: yes, 1984
Sociology 4120: Sociology of Culture with Prof. Clinton S. Herrick studies art, in every form, and its relationship to human society. Lecture 25: art as an occupation.No audio. Title credits misspell "sociology.
Memorial University of Newfoundland. Educational Television Centre; Herrick, Clinton S.
core  

Re-colonizing spaces of memorializing: the case of the Chattri Indian Memorial, UK

open access: yes, 2016
This article inspects the ways that spaces of war memorialization are organized and reorganized through official and unofficial meaning-making activities. It aims to contribute to the discussion of the ‘value’ of memorializing by examining a multifaceted
Ashley, Susan
core   +1 more source

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