Results 41 to 50 of about 3,402,964 (287)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Diminished time-based, but undiminished event-based, prospective memory among intellectually high-functioning adults with autism: Relation to working memory ability. [PDF]

, 2013
Objective: Prospective memory (PM) is the ability to remember to carry out an intended action. Working memory is the ability to store information in mind while processing potentially distracting information.
Lind, Sophie E, Lind, Sophie E., Grainger, C., Lind, S. E., Williams, David M., Grainger, Catherine, Lind, Sophie, Williams, David, Jarrold, Christopher, Jarrold, C., Williams, D. M., Williams, David M   +11 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Conservative Turn in Memory Policies of the the Republic of Korea

RUDN Journal of World History
The subject of the study is public disagreements on certain issues of Korean history. The study aims to determine the theoretical principles underlying the memory policies of the conservative government of Yun Seokyeol.
Natalia Nikolaevna Kim
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Ramping turn-to-turn loss and magnetization loss of a No-Insulation (RE)Ba2Cu3Ox high temperature superconductor pancake coil [PDF]

, 2017
This paper is to study ramping turn-to-turn loss and magnetization loss of a no-insulation (NI) hightemperature superconductor (HTS) pancake coil wound with (RE)Ba2Cu3Ox (REBCO) conduc-tors.
Song, H., Hong, Z., Wang, Y., Jin, Z., Yuan, W.   +4 more
core   +4 more sources

Transfer after Working Memory Updating Training. [PDF]

PLoS ONE, 2015
During the past decade, working memory training has attracted much interest. However, the training outcomes have varied between studies and methodological problems have hampered the interpretation of results.
Otto Waris, Anna Soveri, Matti Laine
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Turn-forming propensities and hydrophobicities of turn sequences.

, 2018
Turn-forming propensities and hydrophobicities of turn sequences.
Atsushi Sato (275996), Andre Menez (5374217)   +1 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source