Results 61 to 70 of about 7,257 (236)
Advanced Science, EarlyView.A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu +4 more
wiley +1 more source
The Other Side of Paradise: Glimpsing Slavery in the University's Utopian Landscapes
Southern Spaces, 2010 Diverse college and university campuses with origins before Emancipation embody a potent paradox. Architecturally and spatially, they present tangible models of idealized utopian spaces, earthly apparitions of the promise of Heaven.
Mark Auslander
doaj +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
Southern Spaces, 2007 Through an extensive archive of photographs and interviews begun in the mid-1990s, Rob Amberg documents the construction of a nine-mile section of US Interstate Highway 26 (I-26) through rural, mountainous Madison County, North Carolina.
Rob Amberg
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Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Advanced Science, EarlyView.Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu +11 more
wiley +1 more source
Southern Spaces, 2011 Since 2007, Susan Harbage Page has photographed objects left at the US–Mexico border, both on site in the Rio Grande Valley, and in her studio. In this photo essay, Inés Valdez comments on the significance of Harbage Page's images of the traces left by ...
Susan Harbage Page, Inés Valdez
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Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Southern Spaces, 2005 Poet Natasha Trethewey presents her "Elegy for the Native Guards," April 9, 2005, on Ship Island, Mississippi. Trethewey is the author of Domestic Work (2000) and Bellocq's Ophelia (2002). Her upcoming Native Guard will be published in 2006. Trethewey's
Natasha Trethewey
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Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source