Results 21 to 30 of about 1,973,540 (188)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Re-defining discontinuity: Implications for the functions of dreaming [PDF]

, 2011
Hobson and Schredl’s dialogue (2011) raised important questions concerning the operationalisation of continuity across sleep and wake, especially in contrast to discontinuity, and questioned the potential functionality of such continuity.
Malinowski, Josie, Horton, CL, Malinowski, J, Horton, Caroline L.   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Effects of Apolipoprotein E Genotype on the Off-Line Memory Consolidation [PDF]

, 2012
Spontaneous brain activity or off-line activity after memory encoding is associated with memory consolidation. A few recent resting-state functional magnetic resonance imaging (RS-fMRI) studies indicate that the RS-fMRI could map off-line memory ...
Wang, De-Yi, Kiviniemi, Vesa, Zang, Yu-Feng, Zhu, Chao-Zhe, Zuo, Xi-Nian, Han, Xiu-Jie, Yan, Chao-Gan, Li, Su-Fang, Zang, YF (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China., Liu, Dong-Qiang, He, Yong   +10 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Role of adult neurogenesis in hippocampal-cortical memory consolidation [PDF]

, 2014
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical ...
Kaoru Inokuchi, Kitamura, Takashi, Inokuchi, Kaoru, Takashi Kitamura   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Accelerated long-term forgetting can become apparent within 3 - 8 hours of wakefulness in patients with Transient Epileptic Amnesia [PDF]

, 2014
Objective: Accelerated Long-term Forgetting (ALF) is typically defined as a memory disorder in which information that is learned and retained normally over standard intervals (~30 minutes) is forgotten at an abnormally rapid rate thereafter. ALF has been
Dewar, Michaela, Della Sala, Sergio, Dewar, M, Butler, Christopher, Della Sala, S, Zeman, Adam Z J, Zeman, A, Butler, C, Zeman, Adam, Hoefeijzers, Serge, Dewar, Michaela ; id_orcid, Hoefeijzers, S   +11 more
core   +1 more source