Results 51 to 60 of about 53,681 (313)

Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

eLife, 2017
Following learning, increased coupling between spindle oscillations in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory consolidation.
Frances Xia, Blake A Richards, Matthew M Tran, Sheena A Josselyn, Kaori Takehara-Nishiuchi, Paul W Frankland   +5 more
doaj   +1 more source

Prefrontal stimulation as a tool to disrupt hippocampal and striatal reactivations underlying fast motor memory consolidation

Brain Stimulation, 2023
Background: Recent evidence suggests that hippocampal replay in humans support rapid motor memory consolidation during epochs of wakefulness interleaved with task practice.
Mareike A. Gann, Nina Dolfen, Bradley R. King, Edwin M. Robertson, Geneviève Albouy   +4 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

The Roles of Protein Expression in Synaptic Plasticity and Memory Consolidation

Frontiers in Molecular Neuroscience, 2014
The amount and availability of proteins are regulated by their synthesis, degradation, and transport. These processes can specifically, locally, and temporally regulate a protein or a population of proteins, thus affecting numerous biological processes ...
Tali eRosenberg, Shunit eGal-Ben-Ari, Daniela C. Dieterich, Daniela C. Dieterich, Daniela C. Dieterich, Michael R. Kreutz, Noam E. Ziv, Eckart D. Gundelfinger, Eckart D. Gundelfinger, Eckart D. Gundelfinger, Kobi eRosenblum, Kobi eRosenblum   +11 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Resolving transitions between distinct phases of memory consolidation at high resolution in Caenorhabditis elegans

iScience
Summary: Memory consolidation following learning is a dynamic and complex process comprising several transitions between distinct memory phases. Although memory consolidation has been studied extensively, it remains difficult to draw an integral ...
Netanel Cohen, Ithai Rabinowitch
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Sleep-related Memory Consolidation in Schizophrenia

Türk Uyku Tıbbı Dergisi, 2022
Sleep disturbances are a prominent feature of many neuropsychiatric disorders. Although disturbed sleep is also a prominent feature of schizophrenia, its relationship with the pathophysiology, signs and symptoms of schizophrenia is not fully understood ...
Emine Nur Çorum
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Entorhinal cortical delta oscillations drive memory consolidation

Cell Reports, 2023
Summary: Long-term memories are formed by creating stable memory representations via memory consolidation, which mainly occurs during sleep following the encoding of labile memories in the hippocampus during waking.
Juhee Haam, Suman Gunin, Leslie Wilson, Sydney Fry, Briana Bernstein, Eric Thomson, Hayden Noblet, Jesse Cushman, Jerrel L. Yakel   +8 more
doaj   +1 more source