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The digital turn in memory studies

open access: yesMemory Studies, 2023
This article examines the changes experienced by collective memory in the digital era. Contrary to the thesis that digital memory entails a new type of memory, which is radically different from the traditional conceptualization, I argue that the practice of digital memory materializes and implements the theoretical claims made by Memory Studies since ...
openaire   +2 more sources

The use of restrictive practices in the everyday care of people living with dementia in hospital settings: an ethnographic study

open access: yesHealth and Social Care Delivery Research
Background Inquiries, National Health Service serious incident reviews and media reports identify people living with dementia at significant risk of experiencing restrictive practices during an unscheduled acute hospital admission. However, to date, this
Andy Northcott   +5 more
doaj   +1 more source

Representation of a prominent public figure of Yuriy Fedkovych in Chernivtsi’s cultural memory narrative

open access: yesНауковий вісник Чернівецького національного університету імені Юрія Федьковича. Історія, 2022
The body of the article goes on to discuss the problem of a new portrayal and interpretation of a significant impact of the Ukrainian outstanding writer and a public figure Yuriy Fedkovych on the cultural memory of the capital of Bukovyna – Chernivtsi ...
Світлана Герегова
doaj  

“But what a place / to put a piano”: Nostalgic Objects in Robert Minhinnick’s "Diary of the Last Man"

open access: yesText Matters, 2019
In 2003, Martin Rees referred to the present as “mankind’s final century.” A few years later, Slavoj Žižek wrote that humankind is heading towards “apocalyptic zero-point,” when the ecological crisis will most probably lead to our complete destruction ...
Agata Handley
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings

open access: yesNature Communications
Blood-based biomarkers for screening may guide tau positrion emissition tomography (PET) scan referrals to optimize prognostic evaluation in Alzheimer’s disease.
Wagner S. Brum   +17 more
doaj   +1 more source

Perceived walking difficulties in Parkinson’s disease – predictors and changes over time

open access: yesBMC Geriatrics, 2021
Background People with Parkinson’s disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life.
Magnus Lindh-Rengifo   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

‘Piazzale Loreto’ in Milan, from the ‘20s to the Present. Architectural and Historical Memories from a Space of Dis/Affection [PDF]

open access: yesUniversity of Bucharest Review. Literary and Cultural Studies Series, 2016
This study aims to highlight the role played by a significant public place of Milan, ‘piazzale Loreto’ that, throughout time, has been at the centre of attention for many reasons, gradually becoming a place of dis/affection and contestation.
Silvia Colombo
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

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