Results 101 to 110 of about 24,136 (236)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1 [PDF]

, 2013
Functional pancreatic neuroendocrine tumours (PNETs) are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycaemia. The major genetic alterations in sporadic insulinomas are still unknown.
Cai, Jie, Cao, Yanan, Gao, Zhibo, Huang, Xuanlin, Jiang, Xiaohua, Jiang, Xiuli, Jin, Xiaolong, Li, Lin, Li, Yanli, Li, Yingrui, Liu, Li, Ning, Guang, Peng, Ying, Qin, Guijun, Shan, Aijing, Wang, Jiaqian, Wang, Jun, Wang, Weiqing, Wei, Qing, Zhao, Jiajun   +19 more
core   +1 more source

ASO Author Reflections: Severe Morbidity After Major Surgery in Patients with MEN1 [PDF]

, 2021
Dirk‐Jan van Beek, Wessel M.C.M. Vorselaars, Inne H.M. Borel Rinkes, Menno R. Vriens   +3 more
openalex   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. [PDF]

, 2017
The CABLES1 cell cycle regulator participates in the adrenal-pituitary negative feedback, and its expression is reduced in corticotropinomas, pituitary tumors with a largely unexplained genetic basis.
Assié, Guillaume, Balsalobre, Aurelio, Bertherat, Jérôme, Chittiboina, Prashant, Dimopoulos, Aggeliki, Drouin, Jacques, Faucz, Fabio R, Gaillard, Stephan, Gam, Ryhem, Gauthier, Yves, Hernández-Ramírez, Laura C, Kay, Denise M, Lane, John, Lodish, Maya B, Mills, James L, Neou, Mario, Pankratz, Nathan, Stratakis, Constantine A, Trivellin, Giampaolo, Valdés, Nuria, Villa, Chiara   +20 more
core   +2 more sources

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source

Intraoperative Decision-Making and Technical Aspects of Parathyroidectomy in Young Patients With MEN1 Related Hyperparathyroidism

Frontiers in Endocrinology, 2018
One in 5,000 to 1 in 50,000 births have multiple endocrine neoplasia type 1 (MEN1). MEN1 is a hereditary syndrome clinically defined by the presence of two of the following endocrine tumors in the same patient: parathyroid adenomas, entero-pancreatic ...
Priscilla F. Nobecourt, Jonathan Zagzag, Elliot A. Asare, Nancy D. Perrier   +3 more
doaj   +1 more source

The CR structure of minimal orbits in complex flag manifolds

, 2005
Let \^G be a complex semisimple Lie group, Q a parabolic subgroup and G a real form of \^G. The flag manifold \^G/Q decomposes into finitely many G-orbits; among them there is exactly one orbit of minimal dimension, which is compact.
Altomani, Andrea, Medori, Costantino, Nacinovich, Mauro   +2 more
core  

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

Genetic Landscape and Clinical Manifestations of Multiple Endocrine Neoplasia Type 1 in a Korean Cohort: A Multicenter Retrospective Analysis [PDF]

Endocrinology and Metabolism
Background Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in multiple endocrine organs, caused by variants in the MEN1 gene.
Boram Kim, Seung Hun Lee, Chang Ho Ahn, Han Na Jang, Sung Im Cho, Jee-Soo Lee, Yu-Mi Lee, Su-Jin Kim, Tae-Yon Sung, Kyu Eun Lee, Woochang Lee, Jung-Min Koh, Moon-Woo Seong, Jung Hee Kim   +13 more
doaj   +1 more source