Results 21 to 30 of about 1,690 (123)

Flush after unilateral adrenalectomy [PDF]

Romanian Journal of Medical Practice, 2020
MEN (multiple endocrine neoplasia) type 2A syndrome, a rare autosomal dominant condition of RET proto-oncogene gain-of-function mutations mostly involves medullar thyroid cancer and pheocromocytoma (40-50%) while primary hyperparathyroidism has a less ...
Florica SANDRU, Mihai Cristian DUMITRASCU, Ana VALEA, Simona Elena ALBU, Anda DUMITRASCU, Mara CARSOTE   +5 more
doaj   +1 more source

A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion

Case Reports in Endocrinology, 2020
Background. Multiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by RET proto-oncogene mutation. Two different clinical variants of MEN2 are known (MEN2A and MEN2B): medullary thyroid carcinoma (MTC) almost always present and
Carlotta Giani, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Alessia Tacito, Laura Valerio, Laura Agate, Clara Ugolini, Michele Marinò, Fulvio Basolo, Alessandro Franchi, Simona Borsari, Angela Michelucci, Cesare Selli, Gabriele Materazzi, Filomena Cetani, Rossella Elisei   +16 more
doaj   +1 more source

Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway. [PDF]

PLoS ONE, 2015
Constitutive activation of the Rearranged during Transfection (RET) proto-oncogene leads to the development of MEN2A medullary thyroid cancer (MTC). The relatively clear genotype/phenotype relationship seen with RET mutations and the development of MEN2A
Lyle J Burdine, Marie Schluterman Burdine, Linley Moreland, Brad Fogel, Lisa M Orr, Jennifer James, Richard H Turnage, Alan J Tackett   +7 more
doaj   +1 more source

Medullary thyroid carcinoma and RET molecular testing: A virtual tumor board on clinical decision-making. [PDF]

CA Cancer J Clin
CA: A Cancer Journal for Clinicians, Volume 76, Issue 3, May/June 2026.
Kallas-Silva L, Dos Santos Valsecchi VA, Hoff AO, Farias EC, de Barros Maciel RM, Riera R, Ward LS, Cunha LL.   +7 more
europepmc   +2 more sources

Transcriptional landscape of a RETC634Y-mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers

Stem Cell Research, 2018
Summary: MEN2A is a hereditary cancer-predisposing syndrome that affects patients with germline RET mutations. The effects of this oncogenic tyrosine kinase in the context of primitive stem cells are not known.
Julien Hadoux, Christophe Desterke, Olivier Féraud, Mathieu Guibert, Roberta Francesca De Rose, Paule Opolon, Dominique Divers, Emilie Gobbo, Frank Griscelli, Martin Schlumberger, Annelise Bennaceur-Griscelli, Ali G. Turhan   +11 more
doaj   +1 more source

Caracterização molecular de uma família com nem2a e suas implicações clínicas.

Acta Médica Portuguesa, 2003
MEN2A is an autossomal dominant cancer syndrome characterised by the presence of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. Germline mutations of the RET protooncogene constitute the molecular defect and can be identified
M C Lemos, F Carrilho, F J Rodrigues, M Cavalheiro, F J Regateiro, M M Ruas   +5 more
doaj   +1 more source

Coexistence of Multiple Endocrine Neoplasia Type 2B and Centri-Acinar Emphysema With Alpha-1 Antitrypsin Deficiency: A Case Report. [PDF]

Respirol Case Rep
We report on a 32‐year‐old female patient with a very rare coexistence of alpha‐1 antitrypsin deficiency (AATD) and multiple endocrine neoplasia type 2B (MEN2B). Both conditions can affect breathing and may hide each other's symptoms, leading to delayed diagnosis.
Mohammadifard MJ, Taghinejad A, AghaeiMeybodi F.   +2 more
europepmc   +2 more sources

Metastatic thyroid cancer after thyroidectomy in patient with MEN2A syndrome: a case report

Liječnički vjesnik, 2023
Multiple Endocrine Neoplasia Type 2 (MEN 2) is a complex hereditary disorder with a genetic predisposition toward the development of endocrine tumors.
Ana Čala, Tina Dušek
doaj   +1 more source

Disease-modifying polymorphisms and C609Y mutation of RET associated with high penetrance of phaeochromocytoma and low rate of MTC in MEN2A

Endocrinology, Diabetes & Metabolism Case Reports, 2016
Mutations of the rearranged during transfection (RET) proto-oncogene, located on chromosome 10q11.2, cause multiple endocrine neoplasia type 2A (MEN2A).
Rowena Speak, Jackie Cook, Barney Harrison, John Newell-Price   +3 more
doaj   +1 more source

Measuring Interactional Competence in a Japanese University EFL Speaking Context

International Journal of Applied Linguistics, EarlyView.
ABSTRACT The ability to interact is an integral aspect of speaking proficiency. Therefore, methods of assessing interaction need to be incorporated into second language (L2) speaking tests. The main purpose of this exploratory study is to attempt to quantify interactional competence (IC) in a Japanese university EFL (English as a foreign language ...
Paul Garside
wiley   +1 more source