Results 21 to 30 of about 1,473 (176)

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Inclusive or Inauthentic? Consumer Scepticism Towards LGBTQ‐Themed Cause‐Related Marketing

Journal of Consumer Behaviour, EarlyView.
ABSTRACT Cause‐related marketing (CRM) is widely used to signal corporate social responsibility and engage ethically motivated consumers, yet its effectiveness remains contested in identity‐sensitive domains such as LGBTQ inclusion. Drawing on Social Identity Theory and Attribution Theory, this research examines how LGBTQ cause identification ...
Wilson N. Ndasi
wiley   +1 more source

Neuroimaging of the ictal–interictal continuum: Where do we stand? A systematic review and meta‐analysis of current evidence

Epilepsia Open, EarlyView.
Abstract Objective Patterns within the ictal–interictal continuum (IIC) are frequently encountered in critically ill patients undergoing continuous electroencephalographic studies and may reflect ongoing ictal activity or secondary brain injury. Peri‐ictal neuroimaging abnormalities (PNA) have been described in association with status epilepticus (SE),
Panagiota‐Eleni Tsalouchidou, Kateriine Orav, Tiago Lerda‐Casaccia, Leona Möller, Georgios Tsivgoulis, Anastasios Bonakis, Lukas Machegger, Giorgi Kuchukhidze, Susanne Knake, Eugen Trinka, Pilar Bosque‐Varela   +10 more
wiley   +1 more source

Transforming Agricultural Water Management Through the Water–Energy–Food Nexus: Trends, Opportunities, Barriers and Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Agricultural water management (AWM) is increasingly transitioning towards transformative thinking, where interconnected sectors, including water, energy and food, are managed holistically. Trends point towards cross‐sectoral and harmonised strategies to optimise water use efficiency and productivity, integrate renewable energy, promote ...
Luxon Nhamo, Cuthbert Taguta, Sylvester Mpandeli, Tinashe Dirwai, Stanley Liphadzi, Tafadzwanashe Mabhaudhi   +5 more
wiley   +1 more source

Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross‐Sectional Analysis on Cement Plant Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Heavy metal exposure is known to have various effects on renal function and blood glucose regulation. The main objective of this study was to evaluate the effects of cement dust and some metal (cadmium, manganese, nickel, and zinc) exposure on blood glucose and renal function parameters in male cement plant workers.
Duygu Seyhan Erdoğan, Fatma Bozdag, Fatıma Betül Topcu, Osman Burak Demirbas, Sultan Pinar Cetintepe, Mustafa Necmi Ilhan   +5 more
wiley   +1 more source

Efficacy of Hand Gestures and the Hand as Foot Teaching Method Compared to Traditional Methods in Medical and Dental Education: A Scoping Review

Journal of Dental Education, EarlyView.
ABSTRACT Objective The “Hand‐as‐Foot” teaching method is an innovative, hands‐on approach that uses gesture‐based movements to represent anatomical structures and functions. It has been used successfully in medical education to help simplify and communicate complex ideas. However, its use in dental education remains relatively unexplored.
Shivangi Vats, Manuel S. Thomas, Vinod Jathanna   +2 more
wiley   +1 more source

Rethinking Plasticity in Sponges

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
This systematic review critiques the conceptual confusion caused by the indiscriminate use of “plasticity” in Porifera literature, revealing that researchers often overlook genetic variability and fail to distinguish between real‐time environmental responses and natural selection.
Laura Oliveira, Emilio Lanna
wiley   +1 more source