Results 341 to 350 of about 314,978 (365)

Mendelian Randomization as a Tool for Cardiovascular Research: A Review.

JAMA cardiology, 2023
Importance Mendelian randomization (MR) is a statistical approach that has become increasingly popular in the field of cardiovascular disease research.
Michael G Levin, Stephen Burgess
semanticscholar   +1 more source

Mendelian and non-Mendelian heredity: a reappraisal

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
The first report of a non-Mendelian gene (Correns 1908) appeared just eight years after the rediscovery of Mendel’s laws and, in this sense, Mendelian and non-Mendelian heredity have both been available for analysis and comparison for almost sixty years.
openaire   +2 more sources

Mendelian randomization for nephrologists

Kidney International, 2023
Confounding is a major limitation of observational studies. Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data.
Ellen Dobrijevic, Anita van Zwieten, Krzysztof Kiryluk, Andrew J. Grant, Germaine Wong, Armando Teixeira-Pinto   +5 more
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On the origins of the Mendelian laws

Journal of Heredity, 1984
The two laws usually attributed to Mendel were not considered as laws by him. The first law, the law of independent segregation occurs in Mendel's paper as an assumption or hypothesis. Hugo de Vries refers to this as a law discovered by Mendel. This appears to be the first use of an expression equivalent to Mendel's law.
F, Monaghan, A, Corcos
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Mendelian Phenotypes in the Netherlands

Human Heredity, 1993
We report here a database listing Mendelian phenotypes described in the Netherlands and/or in populations originating from this country, and describe the results of a quantitative analysis of the database. The database is specifically directed at the presence, frequency and origin of the phenotypes.
J B, Verheij, L P, ten Kate
openaire   +2 more sources

A Reintroduction to Mendelian Genetics

Cancer Investigation, 1997
The origin of modern genetics is often credited to Gregor Mendel (1865). The fact, if not the exact date, is as well known to every modern schoolchild as the Battle of Hastings. Mendel alone didn't get us to where we are today. Even our understanding of Mendelian inheritance is dependent on the contributions of those who discovered and defined genes ...
M. E. Hodes, Stephen R. Dlouhy
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Maverick against the Mendelians

Scientific American, 2008
The article describes a theory that has been suggested by scientist Michael Wigler, which attempts to explain the genetic basis of autism. The author explains that Wigler's theory relies on the assumption that women are more likely to carry the gene and pass it on to their male offspring than to develop the disease themselves. INSET: MICHAEL WIGLER.
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Mendelian etiologies of stroke

Annals of Neurology, 1987
AbstractThere are many genetic disorders associated with an increased risk for stroke that may easily be overlooked in the valuation of both adult and pediatric acute stroke victims. The recognition of a genetic disorder as the cause of a stroke has important implications not only for the immediate care of the stroke victim, but often also for others ...
M, Natowicz, R I, Kelley
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Polygenic Mendelian Randomization

Cold Spring Harbor Perspectives in Medicine, 2020
Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR.
openaire   +2 more sources

The history of the Mendelian gene.

Rivista di biologia, 2007
The concept of heredity arose when the ancient philosophers and scientists felt the need to explain the variation and organic evolution phenomena. The ideas about inheritance developed before Mendel were significant in the construction of the Mendelian concept of gene.
openaire   +2 more sources