trioPhaser: using Mendelian inheritance logic to improve genomic phasing of trios [PDF]
BMC Bioinformatics, 2021 Background When analyzing DNA sequence data of an individual, knowing which nucleotide was inherited from each parent can be beneficial when trying to identify certain types of DNA variants.
Dustin B. Miller, Stephen R. Piccolo
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A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy [PDF]
Nature Communications, 2019 Genetic variants in RP1 can cause hereditary retinal degeneration (HRD). Here, in a genomic screen of 331 Japanese HRD patients, the authors identify a near-polymorphic RP1 variant that causes Mendelian HRD in trans with an Alu insertion and otherwise is
Konstantinos Nikopoulos +27 more
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Mendelian Inheritance and the Purity of the Gametes [PDF]
Science, 1906 n ...
E. B. Wilson
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Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross [PDF]
BMC Genetics, 2010 Background Transmission ratio distortion (TRD), defined as statistically significant deviation from expected 1:1 Mendelian ratios of allele inheritance, results in a reduction of the expected progeny of a given genotype.
de Villena Fernando PM +6 more
doaj +5 more sources
Celer: an Efficient Program for Genotype Elimination [PDF]
Electronic Proceedings in Theoretical Computer Science, 2010 This paper presents an efficient program for checking Mendelian consistency in a pedigree. Since pedigrees may contain incomplete and/or erroneous information, geneticists need to pre-process them before performing linkage analysis.
Nicoletta De Francesco +2 more
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Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding [PDF]
Scientific Reports, 2021 High voltage-activated Cav2.3 R-type Ca2+ channels and low voltage-activated Cav3.2 T-type Ca2+ channels were reported to be involved in numerous physiological and pathophysiological processes.
Anna Papazoglou +4 more
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Assessing non-Mendelian inheritance in inherited axonopathies. [PDF]
Genet Med, 2020 Inherited axonopathies (IA) are rare, clinically and genetically heterogeneous diseases that lead to length-dependent degeneration of the long axons in central (hereditary spastic paraplegia [HSP]) and peripheral (Charcot-Marie-Tooth type 2 [CMT2]) nervous systems.
Bis-Brewer DM +19 more
europepmc +7 more sources
Efficient allelic-drive in Drosophila [PDF]
Nature Communications, 2019 Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors develop an allelic-drive for selective inheritance of a desired allele.
Annabel Guichard +9 more
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Mendelian Inheritance in Prunus Hybrids [PDF]
Journal of Heredity, 1912 n ...
S. A. Beach, T. J. Maney
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Clarifying Mendelian vs non-Mendelian inheritance. [PDF]
GeneticsAbstract Gregor Mendel developed the principles of segregation and independent assortment in the mid-1800s based on his detailed analysis of several traits in pea plants. Those principles, now called Mendel's laws, in fact, explain the behavior of genes and alleles during meiosis and are now understood to underlie “Mendelian inheritance”
Strome S +4 more
europepmc +4 more sources