Results 91 to 100 of about 96,085 (345)
The Hidden Complexity of Mendelian Traits across Natural Yeast Populations
Cell Reports, 2016 Mendelian traits are considered to be at the lower end of the complexity spectrum of heritable phenotypes. However, more than a century after the rediscovery of Mendel’s law, the global landscape of monogenic variants, as well as their effects and ...
Jing Hou +7 more
doaj +1 more source
Beyond the simplicity of Mendelian inheritance
Comptes Rendus. Biologies, 2016 Elucidating the underlying rules that govern the phenotypic diversity observed in natural populations is an old but still unaccomplished goal in biology. In 1865, Gregor Mendel paved the way for the dissection of the underlying genetic basis of traits by setting out to understand the principles of heredity.
openaire +2 more sources
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
Advanced Science, EarlyView.This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv +6 more
wiley +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract Late blight (LB), caused by the oomycete Phytophthora infestans, is one of the most destructive diseases of the cultivated tomato (Solanum lycopersicum L.) and potato (Solanum tuberosum L.) worldwide. Genetic changes in the pathogen have resulted in the emergence of new genotypes, overcoming formerly effective fungicides or host resistance ...
Matthew T. Sullenberger +4 more
wiley +1 more source
Frontiers in Genetics, 2014 Fetal alcohol spectrum disorder (FASD) presents a collection of symptoms representing physiological and behavioral phenotypes caused by maternal alcohol consumption.
Elif eTunc-Ozcan +4 more
doaj +1 more source
An alternative to Kitcher's theory of conceptual progress and his account of the change of the gene concept [PDF]
, 2004 The present paper discusses Kitcher’s framework for studying conceptual change and progress. Kitcher’s core notion of reference potential is hard to apply to concrete cases.
Brigandt, Ingo
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Inheritance through the cytoplasm [PDF]
, 2022 Most heritable information in eukaryotic cells is encoded in the nuclear genome, with inheritance patterns following classic Mendelian segregation. Genomes residing in the cytoplasm, however, prove to be a peculiar exception to this rule.
Alexander-Lawrie, Bridie +3 more
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Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus
eLife, 2018 Meiosis is a key cellular process of sexual reproduction that includes pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog.
Michael Habig +2 more
doaj +1 more source
Mode of inheritance of deficient corpus callosum in mice [PDF]
, 1982 Many mice of the Inbred strain BALB/cCF have deficient corpus callosum, and a few of them have total absence of this large forebrain commissure. Reciprocal F1 hybrid crosses with the inbred strains A/J, C57BL/6J, and DBA/2J revealed that Inheritance of ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
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An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. [PDF]
, 2018 Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care ...
Bjonnes, Andrew +47 more
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