Results 101 to 110 of about 96,085 (345)

The promise and challenges of characterizing genome‐wide structural variants: A case study in a critically endangered parrot

Molecular Ecology Resources, EarlyView., 2023
Abstract There is growing interest in the role of structural variants (SVs) as drivers of local adaptation and speciation. From a biodiversity genomics perspective, the characterization of genome‐wide SVs provides an exciting opportunity to complement single nucleotide polymorphisms (SNPs). However, little is known about the impacts of SV discovery and
Jana R. Wold, Joseph G. Guhlin, Peter K. Dearden, Anna W. Santure, Tammy E. Steeves   +4 more
wiley   +1 more source

Deep structured learning for variant prioritization in Mendelian diseases

Nature Communications, 2023
Effective computer-aided or automated variant evaluations for monogenic diseases will expedite clinical diagnostic and research efforts of known and novel disease-causing genes.
Matt C. Danzi, Maike F. Dohrn, Sarah Fazal, Danique Beijer, Adriana P. Rebelo, Vivian Cintra, Stephan Züchner   +6 more
doaj   +1 more source

Mendelian inheritance of introrse orientated anthers in Brassica rapa

Czech Journal of Genetics and Plant Breeding, 2022
The inheritance of anther orientation of 154 individuals from two B1 populations of Brassica rapa (syn. Brassica campestris) was evaluated under controlled conditions in a greenhouse.
Jaroslav Salava, Derek Lydiate
doaj   +1 more source

The interplay of microscopic and mesoscopic structure in complex networks [PDF]

, 2010
Not all nodes in a network are created equal. Differences and similarities exist at both individual node and group levels. Disentangling single node from group properties is crucial for network modeling and structural inference. Based on unbiased generative probabilistic exponential random graph models and employing distributive message passing ...
arxiv   +1 more source

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine, EarlyView.
In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
wiley   +1 more source

Easy‐to‐use R functions to separate reduced‐representation genomic datasets into sex‐linked and autosomal loci, and conduct sex assignment

Molecular Ecology Resources, EarlyView., 2023
Abstract Identifying sex‐linked markers in genomic datasets is important because their presence in supposedly neutral autosomal datasets can result in incorrect estimates of genetic diversity, population structure and parentage. However, detecting sex‐linked loci can be challenging, and available scripts neglect some categories of sex‐linked variation.
Diana A. Robledo‐Ruiz, Lana Austin, J. Nevil Amos, Jesús Castrejón‐Figueroa, Daniel K. P. Harley, Michael J. L. Magrath, Paul Sunnucks, Alexandra Pavlova   +7 more
wiley   +1 more source

Scaling‐up RADseq methods for large datasets of non‐invasive samples: Lessons for library construction and data preprocessing

Molecular Ecology Resources, EarlyView., 2023
Abstract Genetic non‐invasive sampling (gNIS) is a critical tool for population genetics studies, supporting conservation efforts while imposing minimal impacts on wildlife. However, gNIS often presents variable levels of DNA degradation and non‐endogenous contamination, which can incur considerable processing costs. Furthermore, the use of restriction‐
Larissa S. Arantes, Jilda A. Caccavo, James K. Sullivan, Sarah Sparmann, Susan Mbedi, Oliver P. Höner, Camila J. Mazzoni   +6 more
wiley   +1 more source

Next Generation Sequencing and Bioinformatics Analysis of Family Genetic Inheritance

Frontiers in Genetics, 2020
Mendelian and complex genetic trait diseases continue to burden and affect society both socially and economically. The lack of effective tests has hampered diagnosis thus, the affected lack proper prognosis.
Aquillah M. Kanzi, James Emmanuel San, Benjamin Chimukangara, Eduan Wilkinson, Maryam Fish, Veron Ramsuran, Tulio de Oliveira   +6 more
doaj   +1 more source

The genetic landscape of polymicrogyria

Annals of Indian Academy of Neurology, 2022
Polymicrogyria (PMG) is a relatively common complex malformation with cortical development, characterized by an exorbitant number of abnormally tiny gyri separated by shallow sulci. It is a neuronal migration disorder.
Jesmy James, Mary Iype, Mithran Omana Surendran, Ayyappan Anitha, Sanjeev V Thomas   +4 more
doaj   +1 more source

Gene-Mating Dynamic Evolution Theory I: Fundamental assumptions, exactly solvable models and analytic solutions [PDF]

Theory in Biosciences 139, 105-134, Springer Nature (2020), 2014
Fundamental properties of macroscopic gene-mating dynamic evolutionary systems are investigated. We focus on a single locus, any number of alleles in a two-gender dioecious population, for a large class of systems within population genetics. Our governing equations are time-dependent differential equations labeled by a set of genotype frequencies.
arxiv   +1 more source