Results 251 to 260 of about 319,715 (326)

Case Report: Compound Heterozygous SCNN1B Mutations Causing Pseudohypoaldosteronism Type 1B2 in Neonatal Twins

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
First Chinese neonatal cases of systemic PHA1B from novel compound‐heterozygous SCNN1B variants (c.585+2T>C; c.1544T>C) presented with life‐threatening hyperkalemia and hyponatremia unresponsive to steroids. Early genetic testing enabled targeted sodium supplementation and potassium‐binding therapy, normalizing electrolytes and underscoring SCNN1B ...
Zhiping Wang, Lijuan Long, Hongjuan Bi
wiley   +1 more source

Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR‐29a‐5p/P53 Signaling in the Tumor Microenvironment

Molecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.
Tianma granule (TMG) inhibits colorectal cancer progression by modulating miR‐29a‐5p/P53 signaling in the tumor microenvironment, reducing stromal senescence and countering pro‐tumorigenic effects. ABSTRACT Chemotherapy‐induced senescence‐associated tumor microenvironment (S‐TME) facilitates colorectal cancer (CRC) progression.
Xiaojuan Tang, Yuan Ren, Yongmin Li, Yuan Lv, Liang Zhao, Yongheng He   +5 more
wiley   +1 more source

Editorial: Consanguinity and rare genetic neurological diseases

Frontiers in Neurology
Suzanne Lesage, Mustafa A. Salih
doaj   +1 more source

Deviation From Genetically Predicted BMI and All‐Cause Mortality: A Cohort Study in the UK Biobank

Obesity, Volume 34, Issue 1, Page 228-236, January 2026.
ABSTRACT Objective The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all‐cause mortality in 208,146 UK Biobank participants. Methods We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed ...
Nuno R. Zilhao, Jie Zhang, Dorret I. Boomsma, Thorkild I. A. Sørensen, Christina C. Dahm   +4 more
wiley   +1 more source

Mendelian Inheritance in Prunus Hybrids

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S. A. Beach, T. J. Maney
openalex   +2 more sources

Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling

The Journal of Pathology, Volume 268, Issue 1, Page 40-53, January 2026.
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto, Norihiko Sakai, Yuta Yamamura, Daichi Kaikoi, Daiki Hayashi, Takahiro Matsuno, Akihiko Koshino, Keisuke Sako, Keisuke Horikoshi, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Megumi Oshima, Shiori Nakagawa, Shinji Kitajima, Akinori Hara, Miho Shimizu, Jumpei Terakawa, Shin‐ichi Horike, Takiko Daikoku, Atsushi Mizokami, Hiroko Ikeda, Moeno Kadoguchi, Hiroshi Arakawa, Sumio Ohtsuki, David Lagares, Takashi Wada, Yasunori Iwata   +27 more
wiley   +1 more source

Functional synergy and genomic linkage of glyphosate resistance traits in Canada fleabane

Pest Management Science, Volume 82, Issue 1, Page 305-318, January 2026.
Stacking target‐site and non‐target‐site glyphosate resistance mechanisms in Conyza canadensis results in strong synergistic effects. This study quantifies gene × gene interactions and maps linked resistance loci, advancing our understanding of herbicide resistance genetics and informing management strategies.
Eric R Page, Sara L Martin, Sydney Meloche, Alyssa Thibodeau, Martin Laforest   +4 more
wiley   +1 more source

Whole‐genome sequencing reveals novel ryanodine receptor mutations P4568L and Y4701D conferring high‐level chlorantraniliprole resistance in Spodoptera litura (Lepidoptera: Noctuidae)

Pest Management Science, Volume 82, Issue 1, Page 815-824, January 2026.
Whole‐genome sequencing identified novel ryanodine receptor mutations P4568L and Y4701D causing >1000‐fold chlorantraniliprole resistance in Spodoptera litura, enabling development of molecular diagnostics for proactive resistance management. Abstract BACKGROUND Spodoptera litura is a significant insect pest that attacks many agricultural crops ...
Yizhou Chen, Lisa Bird, Thi HT Nguyen, Grant A Herron, Duong T Nguyen   +4 more
wiley   +1 more source

Linking the ICRISAT Genebank to Poverty Reduction and Welfare in Malawi

Australian Journal of Agricultural and Resource Economics, Volume 70, Issue 1, Page 165-177, January 2026.
ABSTRACT Genebanks contribute to the development of improved crop varieties through the conservation and supply of diverse germplasm for use in agricultural research by scientists, such as plant breeders. Tracing their contribution to the welfare and poverty impacts of improved varieties on smallholder farmers presents multiple challenges, as the ...
Martin Paul Jr. Tabe‐Ojong, Melinda Smale, Nelissa Jamora, Vania Azevedo   +3 more
wiley   +1 more source

Genomic Perspective on Heterogeneity of Organs and Body Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi, Daniel Raftery, Luigi Ferrucci   +2 more
wiley   +1 more source