Results 81 to 90 of about 96,085 (345)

Hybridisation generates a hopeful monster: a hermaphroditic selfing cichlid [PDF]

, 2016
Compared to other phylogenetic groups, self-fertilization (selfing) is exceedingly rare in vertebrates and is known to occur only in one small clade of fishes.
Garcia-Alonso, Javier, Smith, Alan, Svensson, Ola, Van Oosterhout, Cock   +3 more
core   +1 more source

Determinatino of dominance in mendelian inheritance [PDF]

Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 1909
n ...
openaire   +3 more sources

Using reported pathogenic variants to identify therapeutic opportunities for genetic diseases

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
The increase in size of publicly available variant annotation and Mendelian disease databases have allowed for novel approaches to identify the likely direction of effect of genetic mutations. Specifically, we found a simple ratio of missense mutations is capable of identifying genes likely to cause disease through a gain‐of‐function mechanism ...
Andrew K. Ressler, David B. Goldstein
wiley   +1 more source

A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata) [PDF]

, 2010
Background: Genetic linkage maps are essential tools when searching for quantitative trait loci (QTL). To maximize genome coverage and provide an evenly spaced marker distribution a combination of different types of genetic marker are sometimes used.
Ball, A.D., Birkhead, T.R., Burke, T., Dawson, D.A., Slate, J., Stapley, J.   +5 more
core   +3 more sources

The GhWL1‐GhH1‐GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology

Advanced Science, EarlyView.
This study identified GhWL1 as a key gene involved in regulating leaf development through analysis of a T‐DNA insertion mutant. The GhWL1‐GhH1 complex is shown to positively regulate GhGA2OX1 by directly binding to its promoter, thereby establishing the GhWL1‐GhH1‐GhGA2OX1 module as a critical pathway in leaf development.
Jingjing Zhan, Xiaoshuang Zhang, Ye Wang, Hang Zhao, Yu Chu, Peng Wang, Yanli Chen, Xi Wei, Wenqiang Qin, Menghan Liu, Jie Kong, Fuguang Li, Xiaoyang Ge   +12 more
wiley   +1 more source

Pedigree reconstruction for triploid apple cultivars using single nucleotide polymorphism array data

PLANTS, PEOPLE, PLANET, Volume 5, Issue 1, Page 98-111, January 2023., 2023
Many economically, culturally, and historically important apple cultivars are triploids, which have three copies of each chromosome instead of the more typical two copies in diploids. Despite their prevalence and importance, there have been conflicting reports regarding their origin and their ability to beget diploids.
Nicholas P. Howard, Diego Micheletti, James J. Luby, Charles‐Eric Durel, Caroline Denancé, Hélène Muranty, Matthew Ordidge, Dirk C. Albach   +7 more
wiley   +1 more source

Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. [PDF]

, 2011
Background: Primary lymphoedema describes a chronic, frequently progressive, failure of lymphatic drainage. This disorder is frequently genetic in origin, and a multigenerational family in which eight individuals developed postnatal lymphoedema of all ...
Brice, G, Child, AH, Connell, FC, Hwang, J, Jeffery, S, Kalidas, K, Mansour, S, Mortimer, PS, Onoufriadis, A, Ostergaard, P, Simpson, MA, Trembath, R   +11 more
core   +3 more sources

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Advanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Chenxuan Liu, Peihong Wang, Pengfei Xu, Jinzeng Wang, Zhou Fang, Donghe Li, Zhizhou Xia, Jiaoyang Li, Shiyu Ji, Qianqian Zhang, Min Wu, Shengyue Wang, Ping Liu, Ruibao Ren   +18 more
wiley   +1 more source

Chromosome drives via CRISPR-Cas9 in yeast

Nature Communications, 2020
Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex ...
Hui Xu, Mingzhe Han, Shiyi Zhou, Bing-Zhi Li, Yi Wu, Ying-Jin Yuan   +5 more
doaj   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source