Results 271 to 280 of about 51,589 (295)

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Metformin reduces the risk of frailty: evidence from a Mendelian randomization study. [PDF]

Diabetol Metab Syndr
Chen T, Liu YL, Qiu HN, Lin CY, Wu F, Li JB, Lin JN.   +6 more
europepmc   +1 more source

Identification of PpTHE1, a cell wall integrity sensor regulating the increased duration of harvest window in slow‐melting flesh peach, through the assembly of a chromosome‐level reference genome of Prunus persica

Plant Biotechnology Journal, EarlyView.
Summary Slow‐melting flesh (SMF) in peaches offers many advantages, including easy transportation, maintaining flavour after ripening, an extended harvest window, and reduced losses caused by fruit softening. However, the underlying molecular mechanism remains elusive.
Junren Meng, Shihang Sun, Ang Li, Liang Niu, Akhi Badrunnesa, Lei Pan, Wenyi Duan, Guochao Cui, Zhiqiang Wang, Juan Xu, Wenfang Zeng   +10 more
wiley   +1 more source

Association of lipidome with senility and the mediated effect of metabolites: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Su J, Yang X, Yu Y, Deng J, Zhang G, Yu R, Wang Y.   +6 more
europepmc   +1 more source

A semi‐dominant NLR allele regulates growth and disease resistance in wheat

Plant Biotechnology Journal, EarlyView.
Summary Wheat powdery mildew is a significant threat to wheat production, necessitating the development of disease‐resistant varieties as an economically viable and environmentally sustainable strategy. In this study, we investigated a semi‐dominant mutant, necrosis leaf (necl), which exhibits spontaneous necrotic lesions and enhanced resistance to ...
Shuiquan Tian, Tingting Du, Jianqing Niu, Shusong Zheng, Zhimeng Zhang, Hongwei Li, Qian‐Hua Shen, Hong‐Qing Ling, Yaoqi Si   +8 more
wiley   +1 more source

A Mendelian randomization analysis reveals the role of the skin microbiota in systemic lupus erythematosus. [PDF]

Clin Rheumatol
Yin Y, Zhao J, Tao Z, Wang J.
europepmc   +1 more source

Causal association of cathepsins and endometriosis: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Aru N, Yang C, Chen Y, Liu J.
europepmc   +1 more source

Mendelian Randomization Analysis Reveals Causal Effects of Circulating Metabolites on Hyperaldosteronism. [PDF]

Food Sci Nutr
Zhao C, Chen F, Peng L, Li Q, Pang Y, Yue C.   +5 more
europepmc   +1 more source

Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach. [PDF]

Tob Induc Dis
Lin B, Ma H, Lin Y, Lin T, Han X, Lin M, Gao H.   +6 more
europepmc   +1 more source