Results 81 to 90 of about 5,675 (171)

Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance

The Laryngoscope, Volume 136, Issue 8, Page 3559-3568, August 2026.
In untreated otosclerosis with labyrinthine symptoms, delayed 3D FLAIR MRI rarely demonstrates endolymphatic hydrops but frequently reveals blood–labyrinth barrier (BLB) disruption. BLB enhancement is spatially associated with cochlear endosteal and round window involvement and increases with the severity of the hearing loss phenotype.
Héléna Pencroffi, Sylvain Bourdoncle, Jean Fanet, Stéphane Gargula, Denis Ayache, Loïc Duron, Julien Savatovsky, Guillaume Poillon   +7 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, Volume 13, Issue 39, 13 July 2026.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Symptom Overlap and Neurobiological Similarities Between Posttraumatic Stress Disorder and Tinnitus

Human Brain Mapping, Volume 47, Issue 10, July 2026.
Results from this study showed patterns in which those with PTSD and tinnitus demonstrated decreased functional connectivity between certain brain regions compared to those with only tinnitus and healthy controls. ABSTRACT Many symptoms of posttraumatic stress disorder (PTSD) overlap with the psychological sequelae of tinnitus, including sleep ...
John C. Moring, Fatima T. Husain, Crystal Franklin, Emilia Kaniewska, Quintin Hecht, Amanda Flores, Danielle K. Mullen, Carlos Esquivel, Andrew Fallon, Suheily Lovelace, Patricia A. Resick, Stacey Young‐McCaughan, Alan L. Peterson, Peter T. Fox, for the STRONG STAR Consortium   +14 more
wiley   +1 more source

Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear

International Archives of Otorhinolaryngology, 2019
Introduction Menière’s disease was described in 1861, but there are still uncertainties regarding its pathophysiology and treatment. Endolymphatic hydrops is recognized as a fundamental pathological characteristic of the disease, as a result of an ...
Pedro L. Mangabeira Albernaz
doaj   +1 more source

CGRP‐Targeted Therapy in Vestibular Migraine—How Strong Is the Evidence?

European Journal of Neurology, Volume 33, Issue 7, July 2026.
ABSTRACT Background Medications for migraine prevention targeting the calcitonin gene‐related peptide (CGRP) pathway have substantially reduced symptom burden in many patients that have failed previous treatment strategies. In contrast, data on treatment response to monoclonal antibodies (mAbs) or small molecule receptor antagonists (gepants) in ...
Alexander Andrea Tarnutzer, Patricia Castro Abarca, Diego Kaski   +2 more
wiley   +1 more source

Newly Diagnosed Meniere’s Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine [PDF]

, 2018
Objective: To describe the course of Meniere’s disease with noninvasive treatment during the first few years after initial diagnosis. Methods: A retrospective review of consecutive patients with newly diagnosed definite Meniere’s disease between 2013 and
Florian Christov, Firas Sbeih, Michael B. Gluth   +2 more
core   +1 more source

Understanding Meniere’s Disease in the light of Ayurveda [PDF]

, 2022
Meniere’s Disease is an inner ear disease characterized by episodes of Vertigo, Fluctuating sensorineural hearing loss, Tinnitus and sensation of fullness of ear (aural fullness).  It may be associated with headache, nausea, drop attacks.
Datta Nadgir, Prashanth AS, Anuradha Biserotti   +2 more
core   +1 more source

The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle [PDF]

, 2017
The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and ...
Ishiyama, Paul, Paul Ishiyama, Vinters, Harry V, Ishiyama, Gail, Ivan A. Lopez, Lopez, Ivan A, Ishiyama, Akira, Gail Ishiyama, Akira Ishiyama, Harry V. Vinters   +9 more
core   +1 more source

Allergic diseases and Meniere's disease: a bidirectional Mendelian randomization

Brazilian Journal of Otorhinolaryngology
Objectives: Allergic diseases and Meniere's disease found to have a possible link in observational study. However, the potential causal relationship between the two is unclear.
Hongru Qin, Meng Huang, Weiming Liang, Guojing Wu, Mengjia Tan, Junli Zhang, Wenyong Chen   +6 more
doaj   +1 more source

Importance of clinical tests and radiological findings on the peripheral vestibular function for the diagnosis of Meniere’s disease. [PDF]

, 2019
Introduction Meniere’s disease (MD) is is a disorder of the inner ear which causes episodes of vertigo.The exact pathogenesis of MD is still not clear, but histopathological studies demonstrate an indisputable link with the endolymphatic hydrops ...
Paškonienė, Aistė,
core