Different Contribution of Missense and Loss-of-Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease. [PDF]
MedComm (2020)This study examines the genetic basis of sporadic (SMD) and familial Meniere disease (FMD) by comparing rare protein‐coding variants using exome sequencing and gene burden analysis. FMD patients had a higher accumulation of missense and LoF variants, especially in genes linked to auditory and vestibular function.
Parra-Perez AM +5 more
europepmc +4 more sources
Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease. [PDF]
AJNR Am J Neuroradiol, 2020 BACKGROUND AND PURPOSE: Ménière disease is characterized by endolymphatic hydrops, whereas perilymphatic enhancement on MR imaging has been suggested to be of additional value in diagnosing Ménière disease.
van Steekelenburg JM +8 more
europepmc +2 more sources
Clinical subgroups in bilateral Meniere disease
Frontiers in Neurology, 2016 Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms and tinnitus associated with several comorbidities such as migraine or autoimmune disorders (AD).
Lidia Frejo +17 more
doaj +2 more sources
Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Surgery [PDF]
Clinical and Experimental OtorhinolaryngologyObjectives. The vestibular aqueduct (VA) exhibits significant anatomical variability. These variations and their spatial relationships with neighboring structures may pose technical challenges during endolymphatic sac surgery.
Jeanne Bernard +10 more
doaj +2 more sources
Case Report: Preservation of Otolithic Function After Triple Semicircular Canal Occlusion in a Patient With Intractable Ménière Disease [PDF]
Frontiers in Neurology, 2021 Operative measures are considered when medical treatment fails to control vertigo in patients with intractable Ménière disease. The present report discusses a case in which triple semicircular canal occlusion was performed in a 30-year-old female patient
Yuzhong Zhang +5 more
doaj +2 more sources
Membrane Stress in the Human Labyrinth and Meniere Disease: A Model Analysis
International Archives of Otorhinolaryngology, 2015 Introduction The nature and extent of membrane damage encountered in Meniere disease remains unexplained. Pressure-induced membrane stress may underlie the characteristic hydropic distention.
Daniel J. Pender
doaj +2 more sources
Gravity perception disturbance in patients with unilateral Meniere disease [PDF]
Laryngoscope Investigative Otolaryngology, 2023 Objective To investigate gravity perception disturbance (GPD) in patients with Meniere disease (MD), we classified GPD type based on the results of the head‐tilt perception gain (HTPG) and the head‐upright subjective visual vertical (HU‐SVV) evaluated by
Yoshiro Wada +3 more
doaj +2 more sources
Use of Skull Vibration-Induced Nystagmus in the Follow-up of Patients With Ménière Disease Treated With Intratympanic Gentamicin [PDF]
Clinical and Experimental Otorhinolaryngology, 2023 Objectives. Ménière disease (MD) is an idiopathic disorder that affects hearing and inner ear balance. Intratympanic gentamicin (ITG) is recognized as an effective treatment for uncontrolled MD characterized by persistent vertigo attacks despite therapy.
Susana Marcos Alonso +7 more
doaj +2 more sources
Assessment Tools for Use in Patients with Ménière Disease: An Update. [PDF]
Med Sci Monit, 2017 A number of electrophysiological tests have been proposed for the initial diagnostic assessment or for the follow-up phase of patients affected by Ménière disease.
Ciorba A +5 more
europepmc +2 more sources