Results 261 to 270 of about 145,378 (351)

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

open access: yesBrain Pathology, Volume 36, Issue 2, March 2026.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz   +9 more
wiley   +1 more source

Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study

open access: yesEuropean Journal of Haematology, Volume 116, Issue 3, Page 302-310, March 2026.
ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham   +4 more
wiley   +1 more source

The Contradiction of a Benign Metastatic Meningioma: A Case Report. [PDF]

open access: yesCureus
Ahmed-Issap A   +4 more
europepmc   +1 more source

Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome

open access: yesImmunology, Volume 177, Issue 3, Page 596-612, March 2026.
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada   +9 more
wiley   +1 more source

Survival of nervous system tumors in a Colombian population cancer registry. [PDF]

open access: yesJ Neurooncol
Albarracín Cárdenas CI   +4 more
europepmc   +1 more source

Trouble in the Tank: A Case Report of Fatal Scuticociliate Encephalitis in a Whitetip Reef Shark (Triaenodon obesus)

open access: yesJournal of Fish Diseases, Volume 49, Issue 3, March 2026.
Abstract This case report presents a recent case of scuticociliatosis in a whitetip reef shark (Triaenodon obesus), housed at a zoo (Haus des Meeres Aqua Terra Zoo, Vienna, Austria). Clinical signs such as uncoordinated swimming and body tilt were observed prior to death.
Hella Schwegler   +5 more
wiley   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li   +10 more
wiley   +1 more source

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