Results 31 to 40 of about 12,722 (175)

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie International Edition, EarlyView.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +1 more source

Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Chiara Lötzsch, Jakob Johann Schmidt, Daniel Delev, Roland Coras, Ingmar Blümcke, Ruth Beckervordersandforth   +5 more
wiley   +1 more source

Greater Cochlear Damage in Otogenic Versus Meningogenic Meningitis: Hearing Rehabilitation Implications

The Laryngoscope, EarlyView.
Otogenic route of meningitis was associated with greater cochlear hair cell loss in comparison with the meningogenic one in this otopathology study. Neuronal depletion has been traditionally implicated in failed hearing rehabilitation of post‐meningitis deafness.
Matheus Pedrosa Tavares, Henrique Furlan Pauna, Rafael da Costa Monsanto, Nevra Keskin‐Yilmaz, Breno Lima de Almeida, Norma de Oliveira Penido   +5 more
wiley   +1 more source

Seasonal upsurge of pneumococcal meningitis in the Central African Republic [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2019
A high incidence of bacterial meningitis was observed in the Central African Republic (CAR) from December 2015 to May 2017 in three hospitals in the northwest of the country that are within the African meningitis belt.
Thomas Crellen, V. Bhargavi Rao, Turid Piening, Joke Zeydner, M. Ruby Siddiqui   +4 more
doaj   +1 more source

Stakeholders' perspectives on integrating point‐of‐care diagnostics into forensic death investigations in South Africa

Journal of Forensic Sciences, EarlyView.
Abstract Unnatural and unexplained deaths present critical challenges to the criminal justice, medico‐legal, and public health systems. This study explored forensic professionals' perspectives on the integration of point‐of‐care (POC) diagnostics into unnatural death investigations in South Africa.
Sebueng Ramatsokotla, Bathabile Soul, Kuhlula Maluleke, Lucinda Evert, Stefan Jansen van Vurren, Bettina Chale‐Matsau, Susan Mabotja, Evans Duah, Tivani Mashamba‐Thompson   +8 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Clinically Suspected Invasive Meningococcal Disease Presenting With Purpura Fulminans‐Like Rash, Septic Shock, Multiorgan Dysfunction, and Recovery From ARDS in a Previously Healthy Child

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Clinically suspected invasive meningococcal disease can deteriorate rapidly in previously well children. Prompt recognition of the petechial–purpuric rash with shock, early empirical antibiotics, and aggressive supportive pediatric intensive care are cornerstones of management as multiorgan dysfunction and Acute Respiratory Distress Syndrome ...
Shatha Omar, Adil Alsweis, Amr Khaled, Noor Nabresi, Mosub Qatu, Yahya Qahwash, Mahfouth Jallad   +6 more
wiley   +1 more source

Successful African introduction of a new Group A meningococcal conjugate vaccine: Future challenges and next steps

Human Vaccines & Immunotherapeutics, 2018
The introduction of a new Group A meningococcal conjugate vaccine, MenAfriVacR, has been a important public health success. Group A meningococcal meningitis has disappeared in all countries where the new Men A conjugate vaccine has been used at public ...
F. Marc LaForce, Mamoudou Djingarey, Simonetta Viviani, Marie-Pierre Preziosi   +3 more
doaj   +1 more source

Genetic Variation in Neisseria meningitidis Does Not Influence Disease Severity in Meningococcal Meningitis

Frontiers in Medicine, 2020
Neisseria meningitidis causes sepsis and meningitis in humans. It has been suggested that pathogen genetic variation determines variance in disease severity. Here we report results of a genome-wide association study of 486 N.
Philip H. C. Kremer, John A. Lees, John A. Lees, Bart Ferwerda, Bart Ferwerda, Arie van de Ende, Arie van de Ende, Matthijs C. Brouwer, Stephen D. Bentley, Diederik van de Beek   +9 more
doaj   +1 more source

Complement Factor H‐Based Therapeutics: A Comprehensive Overview

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw   +2 more
wiley   +1 more source