Results 101 to 110 of about 66,731 (293)
PLoS ONE, 2020 IntroductionEculizumab is a licensed treatment for several rare, complement-mediated diseases. Eculizumab use is associated with an approximately 2,000-fold increased meningococcal disease risk.
Catherine H Bozio +2 more
doaj +1 more source
Prospective Detection of Outbreaks [PDF]
arXiv, 2017 This chapter surveys univariate and multivariate methods for infectious disease outbreak detection. The setting considered is a prospective one: data arrives sequentially as part of the surveillance systems maintained by public health authorities, and the task is to determine whether to 'sound the alarm' or not, given the recent history of data.
arxiv
eJHaem, Volume 6, Issue 2, April 2025.ABSTRACT Introduction SB12 demonstrated equivalence to reference eculizumab (ECU) in complement inhibitor‐naïve patients with paroxysmal nocturnal hemoglobinuria (PNH) in the previous randomized, double‐blind, multi‐national, crossover, Phase III study.
Jun Ho Jang +9 more
wiley +1 more source
EPIDEMIOLOGY AND PREVENTION OF MENINGOCOCCAL DISEASE: A CRITICAL APPRAISAL OF VACCINE POLICIES
Педиатрическая фармакология, 2012 Meningococcal disease is characterized by a marked variation in incidence and serogroup distribution by region and over time. In several European countries, Canada and Australia, immunization programs, including universal vaccination of infants or ...
Marco AP Safadi, E David G Mcintosh
doaj +1 more source
Position statement on the management of pregnancy in sickle cell disease
Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 65, Issue 2, Page 183-189, April 2025.Sickle cell disease (SCD) is a hereditary haemoglobinopathy which causes multi‐organ dysfunction. Pregnancies in SCD are high risk with significant maternal and fetal morbidity and mortality, including vaso‐occlusive crises, thrombosis, anaemia, placental insufficiency, fetal growth restriction, preterm birth and medication effects. High level evidence
Mimi Yue +5 more
wiley +1 more source
Iowa Health Focus, September 2004 [PDF]
, 2004 Monthly newsletter for the Iowa Department of Public ...
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The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults [PDF]
, 2005 This study determined whether stressful life events and social support were related to antibody status following both thymus-dependent and thymus-independent vaccinations. Life events in the previous year and customary social support were measured in 57
Burns, Victoria E. +4 more
core +1 more source
DomainScope: A disease network based on protein domain connections [PDF]
arXiv, 2019 Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu +8 more
wiley +1 more source
Meningococcus this Winter : what was going on? [PDF]
, 1996 There was a time in the not very distant past when meningococcus was not being recognised locally. While laboratory sensitivity used to isolate Neisseria meningitidis has not changed in Malta, the frequency of its detection has increased, more so in the ...
Falzon, Dennis
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