Bacterial outer membrane vesicles and vaccine applications [PDF]
, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo +10 more
core +2 more sources
What is the evidence for giving chemoprophylaxis to children or students attending the same preschool, school or college as a case of meningococcal disease? [PDF]
, 2011 We performed a systematic literature review to assess the effectiveness of chemoprophylaxis for contacts of sporadic cases of invasive meningococcal disease (IMD) in educational settings.
Ackerman +30 more
core +2 more sources
Risk of transmitting meningococcal infection by transient contact on aircraft and other transport. [PDF]
, 2009 Contact tracing of persons with meningococcal disease who have travelled on aeroplane or other multi-passenger transport is not consistent between countries.
Hellenbrand, W +4 more
core +3 more sources
Antibiotics for preventing meningococcal infections [PDF]
Cochrane Database of Systematic Reviews, 2011 Meningococcal disease is a contagious bacterial infection caused by Neisseria meningitidis (N. meningitidis). Household contacts have the highest risk of contracting the disease during the first week of a case being detected. Prophylaxis is considered for close contacts of people with a meningococcal infection and populations with known high carriage ...
Zalmanovici Trestioreanu, Anca +4 more
openaire +5 more sources
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
, 2011 Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L +4 more
core +1 more source
From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood [version 1; referees: 3 approved] [PDF]
, 2017 In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of ...
Janowski, Andrew B, Newland, Jason G
core +3 more sources
Endotoxin in meningococcal infections. [PDF]
Archives of Disease in Childhood, 1980 26 children with meningococcal infections were studied to find out the relationaship between plasma and cerebrospinal fluid levels of endotoxin, the clinical outcome, the level of antigen in plasma and cerebrospinal fluid, and indices of complement activation and disseminated intravascular coagulation.
openaire +3 more sources
Dramatic decline of serogrup C meningococcal disease incidence in Catalonia (Spain) 24 months after a mass vaccination programme of children and young people [PDF]
, 2001 STUDY OBJECTIVES The objective of this study was to evaluate the effectiveness of a mass vaccination programme carried out in Catalonia (Spain) in the last quarter of 1997 in response to an upsurge of serogroup C meningococcal disease (SCMD).
Domínguez García, Àngela +4 more
core +2 more sources
Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides
Interdisciplinary Medicine, EarlyView.Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi +3 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw +2 more
wiley +1 more source