Results 61 to 70 of about 32,793 (264)

Development of MenFive®, an affordable pentavalent meningococcal conjugate vaccine (ACYWX) for Africa and beyond

Human Vaccines & Immunotherapeutics
Wide use of the groundbreaking vaccine MenAfriVac® has eliminated serogroup A meningococcal meningitis in the African meningitis belt and paved the way for elimination of all meningococcal disease outbreaks with the development, licensure, and ...
Mark R. Alderson, Katie Regan, Lionel Martellet, Nancy Hosken, Prasad S. Kulkarni, Sambhaji S. Pisal, F. Marc LaForce, Rajeev M. Dhere   +7 more
doaj   +1 more source

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari   +13 more
wiley   +1 more source

A High-Throughput Size Exclusion Chromatography Method to Determine the Molecular Size Distribution of Meningococcal Polysaccharide Vaccine

International Journal of Analytical Chemistry, 2016
Molecular size distribution of meningococcal polysaccharide vaccine is a readily identifiable parameter that directly correlates with the immunogenicity.
Imran Khan, K. M. Taufiqur Rahman, S. M. Saad Us Siraj, Mahbubul Karim, Abdul Muktadir, Arpan Maheshwari, Md Azizul Kabir, Zebun Nahar, Mohammad Mainul Ahasan   +8 more
doaj   +1 more source

Immunogenicity and Safety of a Quadrivalent Meningococcal Tetanus Toxoid­-Conjugate Vaccine (MenACYW­-TT) Administered Concomitantly with Pneumococcal Conjugate Vaccine in Healthy Toddlers in the Russian Federation: a Phase III Randomized Study

Эпидемиология и вакцинопрофилактика, 2023
Relevance. Invasive meningococcal disease (IMD) has high morbidity and mortality, with infants and young children among those at greatest risk.Materials & Methods. A phase III, open-­label, randomized study in toddlers aged 12–23 months evaluated the
L. S. Namazova­-Baranova, O. A. Perminova, T. A. Romanova, V. V. Romanenko, A. N. Galustyan, V. N. Gorodin, I. V. Osipova, V. Yu. Rodnikova, S. M. Kharit, Yu. V. Kovshirina, V. А. Anokhin, S. B’Chir, D. Neveu, M. Bonaparte, G. Áñez, E. Jordanov, M. S. Dhingra, A. V. Goldstein   +17 more
doaj   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., Balbao, J., Cabrera, O., Cuello, M., del Campo, J., Ferro, Valerie A., Gonzales, E., Romeu, B., Zayas, C.   +8 more
core  

Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types [PDF]

, 2011
We describe associations between death from invasive pneumococcal disease (IPD) and particular serogroups and sequence types (STs) determined by multilocus sequence typing (MLST) using data from Scotland.
Andrew Smith, Aspa, Austrian, Avery, Blake, Cecil, Chris Robertson, David Greenhalgh, Diggle, Donald Inverarity, Giles F. S. Edwards, Guimbao Bescós, Huss, Inostroza, Jim McMenamin, Johanna M. C. Jefferies, Karen Lamb, Kendrick, Lamb, Martin, Mathew Diggle, Shapiro, Stuart C. Clarke, Tim J. Mitchell, Weiss   +24 more
core   +3 more sources

Laparoscopic Partial Splenectomy for a Giant Congenital Splenic Cyst in a Child: Case Report and Focused Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT An 11‐year‐old boy with a 16 × 14.5 cm congenital splenic cyst underwent laparoscopic upper‐pole partial splenectomy after negative hydatid workup and vaccination. Recovery was uneventful; histology confirmed epithelial cyst. Spleen‐preserving surgery provided durable symptom relief and preserved function.
Ahmed Alanzi, Dawood Alatefi, Malik Alkabazi, Bano Alsaleh, Khaled M. AlAani, Samah Hakmi   +5 more
wiley   +1 more source

Adesão às novas vacinas conjugadas. Vacina anti-meningocócica e anti-pneumocócica.

Acta Médica Portuguesa, 2004
The new conjugate vaccines against group C meningococcal infection and pneumococcal infection were introduced in Portugal in 2001. In 2001/2002, the media published several alarming news on meningococcal disease and there was an increased demand of those
Laurinda De Queirós, Luis Castro, Maria Carmo Ferreira, Guilherme Gonçalves   +3 more
doaj   +1 more source

Autosplenectomy in a Patient With Autoimmune Polyglandular Syndrome Type 2 (APS‐2)

Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Autoimmune glandular syndrome type 2 is a complex genetic condition where a triad of endocrinopathies is involved, namely, Addison’s disease, type 1 diabetes, and/or autoimmune thyroid disorder. The disease predisposes one to a variety of other autoimmune associations.
Luqman S. Fauzi, Airin Jyoty, Yashwin Sredharan, Manohara Kenchaiah, Osamu Isozaki   +4 more
wiley   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source