Results 101 to 110 of about 99,535 (294)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu   +11 more
wiley   +1 more source

Formation, Manipulation, and Elasticity Measurement of a Nanometric Column of Water Molecules

open access: yes, 2005
Nanometer-sized columns of condensed water molecules are created by an atomic-resolution force microscope operated in ambient conditions. Unusual stepwise decrease of the force gradient associated with the thin water bridge in the tip-substrate gap is ...
D. Sarid   +13 more
core   +1 more source

A STUDY OF THE GENUS MENISCUS [PDF]

open access: yesThe Canadian Entomologist, 1894
½. Length, 7.5 mm.; ovipositor, 7 mm. Black, polished; with orbital lines from occiput to middle of eyes in front, cheeks, clypeus, mandibles except tip, palpi, gula, cuneiform lines on mesonotum, tegulæ, spot in front, lines beneath extending irregularly back to posterior coxæ, sides of scutellum, line on lower pleauræ between anterior and middle coxæ,
openaire   +1 more source

Scalable Manufacturing of Roll‐to‐Roll Slot‐Die Coated Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
Roll‐to‐roll (R2R) slot‐die coating is emerging as a scalable pathway for perovskite solar cells. This mini‐review summarizes advances in ink design, drying control, and electrode integration that enable high‐efficiency flexible devices and modules. Challenges in throughput, stability, and sustainable processing are outlined, guiding the translation of
Farshad Jafarzadeh   +5 more
wiley   +1 more source

Poster 353: Impact of Meniscus and Cartilage Treatment on Return to Sport Following Anterior Cruciate Ligament (ACL) Reconstruction

open access: yesOrthopaedic Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) tears are a common injury in athletes. ACL tears often occur with other injuries, including cartilaginous injuries.
Elle McCormick BBA   +6 more
doaj   +1 more source

Is the present classification of discoid meniscus sufficient?

open access: yesOrthopaedic Journal of Sports Medicine, 2017
Introduction: Although uncommon, the discoid meniscus is quite prone to injury due to its abnormal shape and abnormal histology. The weak or absent peripheral attachment of the discoid meniscus causes instability even after partial meniscectomy ...
Hasan Bombaci   +3 more
doaj   +1 more source

Bioinspired Hierarchical Architecture with Water Transport Channels for Strong Adhesion at the Sweating Interface

open access: yesAdvanced Science, EarlyView.
To address adhesion failure in sweaty epidermal electronics, this study proposes a cross‐species, multi‐scale biomimetic interface. By modeling staged wet adhesion, it integrates self‐regulating liquid bridges with directional drainage. This design ensures stable, high‐performance flexible sensing in complex physiological environments, offering a ...
Jieliang Zhao   +12 more
wiley   +1 more source

Outcome of Meniscus Repair vs Meniscectomy in 40 Years and Older Patient: Systematic Review and Meta Analysis of Direct Comparative Studies

open access: yesOrthopaedic Journal of Sports Medicine
Introduction and Objectives: An older age of the patient is a common reason for choosing meniscectomy instead of meniscus repair. Lately, there have been more meniscus repairs done for all ages.
Muhammad Fakhri Barustan   +1 more
doaj   +1 more source

Meniscus Review

open access: yesSports Medicine and Arthroscopy Review, 2021
Col Chad A, Haley   +2 more
openaire   +3 more sources

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