Results 161 to 170 of about 1,986,249 (280)

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Seeking the root causes of menstrual pain: A systematic review of biomarkers in menstrual effluent. [PDF]

Mol Pain
Kyathanahalli CN, Tu FF, Ashenafi G, Schroer MS, Hellman KM.   +4 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Natural History of Menstrual Pain and Associated Risk Factors in Early Adolescence. [PDF]

J Pediatr Adolesc Gynecol
Modarelli RE, Molsberry SA, Malave-Ortiz S, Calvert M, Lucien J, Denslow S, Zaccaro D, Kamoun C, Shaw ND.   +8 more
europepmc   +1 more source

Machine Learning Analysis Reveals Abnormal Static and Dynamic Low-Frequency Oscillations Indicative of Long-Term Menstrual Pain in Primary Dysmenorrhea Patients. [PDF]

J Pain Res, 2021
Gui SG, Chen RB, Zhong YL, Huang X.
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.
Asimina I. Karampela, Maralyn Druce
wiley   +1 more source

Three‐Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue‐Clearing Imaging

Cell Proliferation, EarlyView.
Our study employed a modified tissue‐clearing method combined with deep imaging for 3D reconstruction of ovarian endometriosis (OEM) lesions, revealing its morphological polymorphism at tissue and cellular levels. Besides, vessels preferentially clustered around the ectopic epithelium, with their distribution pattern strongly linked to the location of ...
Fanyuan Sun, Shuzhen Wang, Jinyan Zhao, Jinhua Leng, Xili Zhu, Chongdong Liu, Jing Chen, Jinming Guo, Bangjing Jiang, Haihe Zhou, Zhuoying Li, Hua Li, Menghui Li, Yongcun Qu   +13 more
wiley   +1 more source

Pain-related support seeking? Situating the response to pain within the social context using a sample of women experiencing menstrual pain. [PDF]

J Behav Med
Marshall EM, Cossen A, Skvarc D, Mikocka-Walus A, Druitt ML, Evans S.   +5 more
europepmc   +1 more source

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium

International Journal of Cancer, 2018
A. Babic, H. Harris, A. Vitonis, L. Titus, S. Jordan, P. Webb, H. Risch, M. Rossing, J. Doherty, K. Wicklund, M. Goodman, F. Modugno, K. Moysich, R. Ness, S. Kjaer, J. Schildkraut, A. Berchuck, C. Pearce, A. Wu, D. Cramer, K. Terry   +20 more
semanticscholar   +1 more source