Results 161 to 170 of about 2,012,791 (358)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Pengaruh Pendidikan Kesehatan Jiwa Keluarga Terhadap Pengetahuan Dan Sikap Pencegahan Kekambuhan Gangguan Jiwa Di Desa Makamhaji Kecamatan Kartasura Kabupaten Sukoharjo [PDF]

, 2017
Mental disorders are psychological or behavioral disorders that occur in person, generally associated with affective disorders, behavioral, cognitive and perceptual.
, Arif Widodo, A.Kep, M.Kes., , Kartinah, S.Kep, Kusumaningtyas, Reny   +2 more
core  

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Prevalence and correlates of probable post-traumatic stress disorder and common mental disorders in a population with a high prevalence of HIV in Zimbabwe [PDF]

, 2018
Ruth Verhey, L.J. Gibson, Jonathan Brakarsh, Dixon Chibanda, Soraya Seedat   +4 more
openalex   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder

BMC Psychiatry
Background Bipolar disorder (BD) is a complex mental illness characterized by different mood states, including depression, mania/hypomania, and euthymia.
Zhenzhu Chen, Zhifang Zhang, Feng Li, Lei Zhao, Qijing Bo, Yuan Zhou, Chuanyue Wang   +6 more
doaj   +1 more source

Mental Health in the Workplace: Situation Analyses, Finland [PDF]

, 2000
[From Introduction] Mental health problems are among the most important contributors to the global burden of disease and disability. Of the ten leading causes of disability worldwide, five are psychiatric conditions: unipolar depression, alcohol use ...
International Labour Organisation, Liimatainen, Marjo-Riitta   +1 more
core   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Acceptability and usability of a WeChat-based intervention for depression in China: A mixed-methods study

Digital Health
Background As research on the use of mobile technology to deliver mental health support grows, the research from China is still very limited. How to design an acceptable and usable mobile mental health service model suitable for China's social and ...
Yuxi Tan, Emily G Lattie, Hui Xiang, Hui Tang, Ziwei Teng, Yan Qiu, Jindong Chen, Haishan Wu   +7 more
doaj   +1 more source

Mental Disorders Associated with Driving under the Influence of Alcohol and/or Drugs: A Register-Based Study [PDF]

, 2012
Karoliina Karjalainen, Tomi Lintonen, Matti Joukamaa, Pirjo Lillsunde   +3 more
openalex   +1 more source