Results 171 to 180 of about 371,442 (311)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation

Advanced Science, EarlyView.
AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You, Breton Asken, Xiaobo Zhou, Qianqian Song   +7 more
wiley   +1 more source

Treating Racial Trauma: The Methodology of a Randomized Controlled Trial of the Healing Racial Trauma Protocol. [PDF]

Behav Sci (Basel)
Osman M, Gran-Ruaz S, Rios Maia da Silva L, Williams MT.   +3 more
europepmc   +1 more source

Multi‐Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis

Advanced Science, EarlyView.
This review systematically analyzes cutting‐edge strategies for boosting nanozyme catalysis through multi‐dimensional synergistic engineering, containing morphology, electronic structure modulation, external stimulation, and machine learning‐aided design.
Yuechun Li, Zhaowen Cui, Chenxin Ji, Cancan Jia, Wentao Zhang, Jianlong Wang, Yizhong Shen   +6 more
wiley   +1 more source

A Fragmented Mind: Altered States of Consciousness and Spirit Possession Between Rituals and Therapy. [PDF]

Integr Psychol Behav Sci
Leo DG.
europepmc   +1 more source

The Role of Medicine In Affirming The Human Adventure [PDF]

, 1993
Polcino, Anna
core   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Artificial Intelligence Is Stereotypically Linked More with Socially Dominant Groups in Natural Language

Advanced Science, EarlyView.
AI is not seen through an unbiased lens. People tend to stereotype AI as competent and link it with socially advantaged groups—such as men, the wealthy, the young, and prestigious occupations—raising concerns that such perceptions may deepen existing social divides rather than bridge them.
Zixi Wang, Haodong Xia, Han Wu Shuang Bao, Yiming Jing, Ruolei Gu   +4 more
wiley   +1 more source

Walking the good road of life: a longitudinal evaluation of American Indian youth suicide prevention training. [PDF]

Front Public Health
Small C, Horn EB, Small G, Webb K, Bull EB, Small MC, Face RC, Pourier W, Montileaux H, Christiansen L, Bradley B, Trottier W, Trottier P, Geboe M, Beamon ER, Fatupaito B, Crawford-Martin B, Ikazoboh Y, Abeke K, Posey S, Milligan K, Kelley A.   +21 more
europepmc   +1 more source

Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity

Advanced Science, EarlyView.
In superficial second‐degree burn wounds, Gb3 turns on genes related to papillary cells through the FGF2 signaling pathway. This increases the ability of cells to break down fibrin and decreases fibrosis, which ultimately prevents scar formation in burn injuries.
Sujie Xie, Runzhi Huang, Weijin Qian, Xinran Ding, Wei Zhang, Yixu Li, Jianyu Lu, Hanlin Sun, Yifan Liu, Yuntao Yao, Bingnan Lu, Minjuan Wu, Zhaofan Xia, Shizhao Ji   +13 more
wiley   +1 more source