Results 191 to 200 of about 4,925,590 (314)

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Prevention of mental health issues in the young: A randomised controlled evaluation of an e-mental health application for young adults to enhance mental health literacy. [PDF]

Internet Interv
Krokos O, Brandhorst I, Gawrilow C, Löchner J.   +3 more
europepmc   +1 more source

The ChatGPT Effect: Investigating Shifting Discourse Patterns, Sentiment, and Benefit–Challenge Framing in AI Mental Health Support [PDF]

Sanguk Lee, Minjin Rheu, Jie Zhuang
openalex   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Validating a positive mental health measure with Portuguese adolescents and exploring associations with mental health perceived competencies. [PDF]

BMC Public Health
Costa TFO, Moreno Poyato AR, Costa PRS, Sequeira CADC, Lluch Canut MT, Sampaio FMC.   +5 more
europepmc   +1 more source

A systematic review of the social determinants of physical and mental health in women with schizophrenia: focus on housing conditions [PDF]

Águeda González‐Rodríguez, M. Natividad, Manuel Jiménez, Leah Susser, Rosa Ayesa‐Arriola, E. Izquierdo, A. Balagué, J. P. Paolini San Miguel, N. Bagué, Adriana Pérez, M. Salvador, José A. Monreal   +11 more
openalex   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Initial effects of Mental Health First Aid training on mental health literacy, social distance, stigma, mental health, and quality of life in the German adult population - Findings from a pilot study. [PDF]

Eur Psychiatry
Schick A, Henn C, Send TS, Maltese S, Deuschle M, Reininghaus U.   +5 more
europepmc   +1 more source

Substance use and mental health in pediatric type 1 diabetes: key predictors of academic failure [PDF]

C. Bey, Taïeb Ach, A. Ben Abdelkarim
openalex   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source