Results 231 to 240 of about 389,895 (298)

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Exploring vagus nerve stimulation in postoperative delirium and dementia. [PDF]

Bioelectron Med
Spicer RM, Olofsson PS, Harrison FE.
europepmc   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Improved quality of life after microvascular decompression for hemifacial spasm. [PDF]

Brain Spine
Weidemeier ME, Bogaczyk V, Schroeder HWS.   +2 more
europepmc   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

D1 and D2 neurons in medial nucleus accumbens participate in chronic orofacial pain phenotypes. [PDF]

Pain Rep
Montes-Ángeles CD, Andrade-González RD, Perrusquia-Hernández E, González-Alva P, García-Hernández AL, Pérez-Martínez IO.   +5 more
europepmc   +1 more source

Secondary schools' preparation for roll‐out of Curriculum for Wales: Case studies of approaches to health and well‐being in the context of national education system reform

The Curriculum Journal, EarlyView.
Abstract Schools are increasingly positioned as key settings for promoting health behaviours and well‐being. Curriculum for Wales (CfW) represents major national reform of the Welsh education system, placing unprecedented focus on health and well‐being for learners in compulsory education (aged 3–16).
Rochelle Embling, Cara O'Donnell, Graham Moore, Sara Jayne Long   +3 more
wiley   +1 more source

Morvan Syndrome Masquerading as Anxiety Disorder: A Case Report Highlighting the Importance of Recognizing Organic Signs in Psychiatric Settings. [PDF]

Int Med Case Rep J
Li J, Li M, Ma H, Hu Y, Dong Q.
europepmc   +1 more source

The Relationship Between Premorbid Weight Status and Eating Disorder Onset in Adolescents: A Longitudinal Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Adolescents with higher weight status (HWS; body mass index > 85th percentile adjusted for age and sex) are at greater risk of eating disorders (ED). This study examined factors associated with HWS adolescents' increased risk and how weight status interacts with other risk factors to influence ED onset. Method Australian adolescents (
Gabriela Tavella, Kris Rogers, Kay Bussey, Phillipa Hay, Nora Trompeter, Deborah Mitchison   +5 more
wiley   +1 more source