Results 61 to 70 of about 2,197,620 (302)

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Clinical Implications of the Localization and Morphological Variability of the Mental Foramen—A Systematic Review

Diagnostics
Background: The mental foramen is a key anatomical structure of the mandible through which the mental nerve and accompanying vessels emerge. Accurate knowledge of its location and morphology is essential for safe dental and surgical procedures in the ...
Mariola Krzykawska-Krupska, Janusz Pach, Piotr Regulski, Jacek Tomczyk, Izabela Strużycka, Kazimierz Szopiński, Katarzyna Osipowicz, Anna Pogorzelska   +7 more
doaj   +1 more source

Effect of Healthy Lifestyle Program on Relapse Prevention among Patients with Substance Use Disorders [PDF]

Tanta Scientific Nursing Journal
Background: Substance used disorder (SUD) is a complicated illness thataffects one’s emotional, social, behavioral, and physical wellbeing. It ischaracterized by the uncontrolled substance usage that has negative effect on theindividual.
Nagwa El Shora, Hossam El-Sawy, Shereen Abo-Elyzeed, Farida Othman   +3 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Immediate Loading After Implant Placement with Relocation of the Inferior Alveolar Nerve in Atrophic Mandibles: A Four-Year Retrospective Evaluation

Oral
Objectives: To retrospectively evaluate the survival rate and complications of immediately loaded implant-supported restorations in atrophic mandibles of patients subjected to inferior alveolar nerve relocation for the placement of dental implants ...
Raffaele Vinci, Saverio Cosola, Gian Luca Pancrazi, Marco Esposito   +3 more
doaj   +1 more source

Jonathan Swift Clinic Approved Centre Inspection Report 28 – 31 March 2017

, 2017
Section 51(1)(a) of the Mental Health Act 2001 (the 2001 Act) states that the principal function of the Inspector shall be to “visit and inspect every approved centre at least once a year in which the commencement of this section falls and to visit and ...
Mental Health Commission (MHC)
core  

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Assessment of Emergence Patterns of the Mental Nerve through the Mental Foramen in Orthopantomograms: An Observational Study

Journal of Nepal Medical Association
Introduction: The mental nerve is a terminal branch of inferior alveolar nerve that leaves mandibular canal via the mental foramen to supply skin of chin and lower lip.
Ruku Pandit, Bikash Desar, Tripti Shakya, Pratiksha Pathak, Sunita Karki, Saru Twanabasu   +5 more
doaj   +1 more source