Results 21 to 30 of about 762,361 (258)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Virtual environment navigation with look-around mode to explore new real spaces by people who are blind [PDF]

, 2017
Background. This paper examines the ability of people who are blind to construct a mental map and perform orientation tasks in real space by using Nintendo Wii technologies to explore virtual environments.
Arons B., David Brown, Fletcher JF., Foulke E., Hadas Gedalevitz, Hill E, Jacobson WH., Lindsay Evett, Lynch K., Max ML, Merabet L, O'Keefe J, Orly Lahav, Patrick Merritt, Porathe T., Sjotrom C, Steven Battersby, Talis V., Van Scoy F   +18 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Ethics of Netnography [PDF]

, 2011
Ethnographic and phenomenological research is commonly used to understand the motivations behind, and consequences of, people’s participation in online spaces; and such qualitative methods are arguably essential to understanding the role that virtual ...
Flintham, Joe
core  

NeuroPlace: categorizing urban places according to mental states [PDF]

, 2017
Urban spaces have a great impact on how people’s emotion and behaviour. There are number of factors that impact our brain responses to a space. This paper presents a novel urban place recommendation approach, that is based on modelling in-situ EEG data ...
A Chamberlain, A Jain, Boris Podobnik, C. Lisetti, E Girden, E Kanjo, E Kanjo, E. Kanjo, E. Kanjo, E. Relph, Eiman Kanjo, Eman M. G. Younis, F Wright, H. Seo, J. Bollen, J. Carletta, J. Healey, J. Wolpaw, K. R. Müller, L. - AlHusain, L. Al-Barrak, Lulwah Al-barrak, M. Rosenbaum, N Alajmi, N. Lathia, N. Thrift, N.El Mawass, P. Shyamal, R. Johnson, R. Miller, R. Ulrich, S Debener, S. Dodds, S. Kaplan, S. Kaplan, S. Reddy, S. Stansfeld, T. Anderson, T. Cresswell, T. Kohlleppel, X Wu, Y. Hama, Z Oralhan   +42 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Parks & Equity: A Framework for Equitable Access in Richmond, VA Parks [PDF]

, 2020
Increasingly, cities are investing in their green spaces, such as open spaces and parks, as a strategy to improve the livability of the city, but also to improve the health of its residents.
Norrell, Kendra
core   +1 more source

The geometry of mental space

, 2023
Human being lives in a three-dimensional geography ecological system. How is this natural space transformed and represented by the mind? In geography and physics, the entity and thing are represented by the Cartesian geometry at low speed level. In psychology its spatiotemporal property was deeply investigated, however, the unified framework of ...
Gao Chuang, Kang Shiyin , Delidaer, Anran Ma, Ya Liu   +4 more
openaire   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source