Results 91 to 100 of about 369,723 (377)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

open access: yesAdvanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich   +8 more
wiley   +1 more source

Study of psychological morbidity & coping mechanisms in family members of persons with mental illnesses

open access: yesArchives of Mental Health, 2010
Background: The psychological morbidity of family members of mentally ill is generally overlooked. This study focuses on the psychological morbidity in family members. Aim: To study psychological morbidity and coping mechanisms used by the family members
P Prasad   +4 more
doaj  

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

open access: yesAdvanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang   +4 more
wiley   +1 more source

The appropriateness of certification of patients to Sterkfontein hospital . [PDF]

open access: yes, 2006
Faculty of Health Sciences School of Medicine 0110993v Tel: 011 984 1268Section 9 and 12 of the South African Mental Health Act No. 18 of 1973 as amended, defines standards and procedures related to the involuntary commitment of mentally ill persons
Khanyile, Vusi Norman
core  

Legal Regulation of Involvement of Persons Undergoing Compulsory Treatment

open access: yesСибирское юридическое обозрение, 2020
The engagement of persons in respect of whom the court imposed coercive measures of a medical nature is carried out through the use of labor therapy methods.
A. V. Vaselovskaya
doaj   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

open access: yesAdvanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng   +11 more
wiley   +1 more source

Stigma of Mental Illness as Cause of Divorce in Byzantium [PDF]

open access: yes, 2009
In Byzantium mentally ill persons were stigmatized, despite the fact that they could live normally. This stigma consisted a very serious problem not only for the patients themselves, but also for their families.Through the legislation of the Byzantine ...
Athanassia Nestor   +2 more
core  

Stiffness‐Tunable Neurotentacles for Minimally Invasive Implantation and Long‐Term Neural Activity Recordings

open access: yesAdvanced Science, EarlyView.
A hydraulically actuated “Neurotentacle” probe offers tunable stiffness for precise implantation into the deep brain without rigid shuttles or dissolvable coatings. It stiffens during insertion to penetrate tissue and softens afterward to minimize damage and enable stable long‐term recordings.
Yang Wang   +8 more
wiley   +1 more source

Mental Health Service in Ghana: a Review of the Case [PDF]

open access: yes, 2017
Mental health care in Ghana has been fraught with several challenges leading to stagnant growth in mental health service delivery and in some cases a severe depreciation in the nature of care. The Government of Ghana pays little or no attention to mental
Adu-Gyamfi, S. (Samuel)
core   +3 more sources

Severity of stigma in psychiatric patients in Mashhad (2013)

open access: yesThe Journal of Qazvin University of Medical Sciences, 2015
Given the importance of stigma in life, behavior and social interaction of psychiatric patients, this cross-sectional study was conducted to determine the severity of stigma in 200 patients referred to Ibn-Sina Hospital in Mashhad during 2013.
A. Heydari, A. Meshkinyazd, P. Soudmand
doaj  

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