Results 121 to 130 of about 8,649 (208)

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

In Silico Structure‐Guided Design of Peptide Candidates Targeting γ‐Secretase Subunit Assembly

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The γ‐secretase complex is a membrane‐embedded protease essential for intramembrane cleavage of substrates such as Notch receptors and the amyloid precursor protein (APP), processes central to cancer progression and Alzheimer's disease (AD) pathology.
Selcen Arı Yuka, Kübra Telli, Alper Yılmaz   +2 more
wiley   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

MERS [PDF]

International Journal of Infectious Diseases, 2016
openaire   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High‐Flow O2 Therapy in Fibrotic Interstitial Lung Disease: A Pilot Physiological Study

Respirology, EarlyView.
We tested the respective effect of high‐flow and supplemental O2 from nasal high‐flow O2 therapy (NHFO2) on dyspnea and exercise tolerance in fibrotic interstitial lung disease. Supplemental O2 and NHFO2 (but not high‐flow) provided improvements in these outcomes at “iso‐O2 saturation” due to reduced ventilatory requirements.
Sarah Thivent, Marylise Ginoux, Samuel Verges, Frédéric Hérengt, Mathieu Marillier   +4 more
wiley   +1 more source

The Evolution of Autonomous Systems for Planetary Cave Exploration: A Review

Journal of Field Robotics, EarlyView.
ABSTRACT The exploration of Subsurface Access Points (SAPs), such as lava tubes on the Moon and Mars, has gained significant interest due to their potential as stable environments shielded from surface radiation and temperature extremes. These sites are considered high‐value targets for detecting water and signs of ancient life, and assessing their ...
Sarah Swinton, Daniel Mitchell, Jamie Blanche, Euan McGookin, David Flynn   +4 more
wiley   +1 more source

Automated object detection based on YOLOv11 for monitoring benthic population dynamics: A new approach combining photogrammetry and open‐source GIS tools applied to sea cucumbers

Remote Sensing in Ecology and Conservation, EarlyView.
This research established a new object detection model based on YOLOv11 to recognise benthic organisms, specifically sea cucumbers, by utilising high‐resolution photogrammetric‐based orthomosaics acquired along infralittoral Mediterranean Sea beds. The model demonstrated impressive performance metrics and, when combined with the Deepness plugin for the
Gian Mario Sangiovanni, Giovanna Jona Lasinio, Daniele Poggio, Gianluca Mastrantonio, Alessio Pollice, Arnold Rakaj, Midhun Mohan, Stefano Moro, Edoardo Casoli, Daniele Ventura   +9 more
wiley   +1 more source

Critical Success Factors and a Modus Operandi Framework for Managing Multi‐Actor Research Partnerships for Sustainable Food Systems

Sustainable Development, EarlyView.
ABSTRACT This paper investigates critical success factors for managing multi‐actor research partnerships for sustainable food systems along their lifecycle. Such partnerships coordinate both internal activities and manage externally funded projects. Drawing on evidence from case studies and workshops with diverse experts, the study identifies critical ...
Mechthild Donner, Damien Guimond, Emmanuelle Lagendijk, Maurine Mamès, Angela Baker, Hugo de Vries   +5 more
wiley   +1 more source