Results 11 to 20 of about 4,448 (111)

Biomarkers. [PDF]

Alzheimers Dement
Abstract Background Plasma biomarkers have demonstrated excellent performances in detecting AD/ADRD‐related brain pathology. However, their relationship with cognitive decline remains unclear. We examined this in a large memory clinic cohort with baseline plasma biomarkers and repeated cognitive assessments over approximately three decades.
Zeng X, Deek RA, Nafash MN, Gu JM, Choity L, Lafferty TK, Farinas MF, Bedison MA, Mercurio RB, Matan C, Gogola A, Kofler JK, Tudorascu DL, Shaaban CE, Lingler JH, Pascoal TA, Klunk WE, Villemagne VL, Ikonomovic MD, Berman SB, Sweet R, Snitz BE, Cohen AD, Kamboh MI, Lopez OL, Karikari TK.   +25 more
europepmc   +2 more sources

Plasma Biomarkers Modulate APOE4 Genotype Risk in Cognitive Decline: Insights from a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background The apolipoprotein E (APOE) 4 genotype is a major genetic risk factor of late‐onset Alzheimer's disease (AD). We examined the link between APOE4 carriage, cognitive decline and AD plasma biomarkers in a large memory clinic cohort with annual assessments spanning up to three decades.
Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

High p‐Tau217 Levels Nullify Age‐related Cognitive Protection in Younger Older Adults [PDF]

Alzheimers Dement
Abstract Background Plasma p‐tau217 is pivotal for diagnosing Alzheimer's Disease (AD) and monitoring its progression, with high p‐tau217 levels associated with amyloid pathology and faster cognitive decline. While younger age is generally expected to provide protection against cognitive decline, the interaction between p‐tau217 levels and age on the ...
Choity L, Zeng X, Deek R, Gu J, Farinas M, Nafash M, Lafferty T, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Berman S, Sweet R, Snitz B, Ikonomovic M, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Diagnostic Performance of Plasma Phospho‐tau217 for Alzheimer's Disease in a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background Phospho‐tau217 (p‐tau217) has emerged as a leading blood‐based biomarker for Alzheimer's disease (AD) and has been recommended by an Alzheimer's Association Workgroup as a biomarker for AD pathology. However, its translational performance in clinical settings remains to be explored.
Sehrawat A, Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Berman S, Sweet R, Ikonomovic M, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Exploring Racial Differences in the Association of Plasma Biomarkers and APOE4 Genotype in a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background The APOE4 is a major genetic risk factor for Alzheimer's disease (AD) and has been shown to impact plasma AD biomarker levels. We utilized a large memory clinic cohort to assess potential differences in this association race.
Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Alzheimer's disease plasma biomarkers are differentially affected by Type II Diabetes Mellitus based on those with Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Type II Diabetes Mellitus (T2DM) remains one of the strongest comorbidities associated with the development of AD. Use of fluid‐based biomarker assays allows for quick, inexpensive, and accurate identification of those at high risk for developing AD or likely already have the disease.
Grizzanti J, Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +26 more
europepmc   +2 more sources

GARIMPO DO TUCANO: ANÁLISE AMBIENTAL DE UM GARIMPO ABANDONADO NO NORDESTE DE GOIÁS

Boletim Goiano de Geografia, 2013
A atividade garimpeira integra as atividades de mineração, contudo sua existência leva à ocorrência de impactos no ambiente, além de envolver a questão social de maneira mais evidente.
Luciana Gonçalves Tibiriçá, Cláudia Valéria de Lima, Nilson Francisquini Botelho   +2 more
doaj   +1 more source

Pênfigo Foliáceo Endêmico (Fogo Selvagem) e sua associação com fatores ambientais e ocupacionais em Ouro Preto, Minas Gerais, Brasil

Cadernos de Saúde Coletiva, 2017
Resumo Pênfigo compreende grupo de doenças bolhosas autoimunes que possuem tendência à progressão, com evolução ilimitada e crônica e com prognóstico potencialmente fatal. O tipo mais comum é o Pênfigo Foliáceo Endêmico (PFE), caracterizado pela presença
Olívia Maria de Paula Alves Bezerra, Márcio Antonio Moreira Galvão, Danilo Jorge da Silva, Cássia Rafaela Leão de Brito, Mariana Carla Santos Rossini, Pedro Marcos Silva e Gonçalves, Lorena de Souza Bueno, Anelise Andrade de Souza   +7 more
doaj   +1 more source

Mercury bioaccumulation in fishes of a paddy field in Southern of Brazil

Acta Limnologica Brasiliensia, 2015
Aim: The aim of present study was to evaluate the Hg concentration in two species of fish (Astyanax sp and Corydoras paleatus) and its potential use as a biomonitor, in order to know if the use of pesticides and fertilizers in paddy can enhance the Hg ...
Vinicius Tavares Kütter, Mateus Tavares Kütter, Emmanoel Vieira Silva-Filho, Eduardo Duarte Marques, Olga Venimar de Oliveira Gomes, Nicolai Mirlean   +5 more
doaj   +1 more source

Asociación de la resistencia al mercurio con la resistencia a antibióticos en Escherichia coli aislados de la costa de Lima-Perú

Revista Peruana de Biología, 2018
El objetivo de este estudio fue investigar la resistencia al mercurio y los antibióticos, y la transferencia de resistencia al mercurio por plásmidos conjugativos en 55 cepas de Escherichia coli aisladas de aguas superficiales del litoral de Lima, Perú ...
Marcos Alejandro Sulca López, Débora Elizabeth Alvarado Iparraguirre   +1 more
doaj   +1 more source