Results 11 to 20 of about 4,524 (159)

Biomarkers. [PDF]

Alzheimers Dement
Abstract Background Plasma biomarkers have demonstrated excellent performances in detecting AD/ADRD‐related brain pathology. However, their relationship with cognitive decline remains unclear. We examined this in a large memory clinic cohort with baseline plasma biomarkers and repeated cognitive assessments over approximately three decades.
Zeng X, Deek RA, Nafash MN, Gu JM, Choity L, Lafferty TK, Farinas MF, Bedison MA, Mercurio RB, Matan C, Gogola A, Kofler JK, Tudorascu DL, Shaaban CE, Lingler JH, Pascoal TA, Klunk WE, Villemagne VL, Ikonomovic MD, Berman SB, Sweet R, Snitz BE, Cohen AD, Kamboh MI, Lopez OL, Karikari TK.   +25 more
europepmc   +2 more sources

Plasma Biomarkers Modulate APOE4 Genotype Risk in Cognitive Decline: Insights from a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background The apolipoprotein E (APOE) 4 genotype is a major genetic risk factor of late‐onset Alzheimer's disease (AD). We examined the link between APOE4 carriage, cognitive decline and AD plasma biomarkers in a large memory clinic cohort with annual assessments spanning up to three decades.
Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

High p‐Tau217 Levels Nullify Age‐related Cognitive Protection in Younger Older Adults [PDF]

Alzheimers Dement
Abstract Background Plasma p‐tau217 is pivotal for diagnosing Alzheimer's Disease (AD) and monitoring its progression, with high p‐tau217 levels associated with amyloid pathology and faster cognitive decline. While younger age is generally expected to provide protection against cognitive decline, the interaction between p‐tau217 levels and age on the ...
Choity L, Zeng X, Deek R, Gu J, Farinas M, Nafash M, Lafferty T, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Berman S, Sweet R, Snitz B, Ikonomovic M, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Diagnostic Performance of Plasma Phospho‐tau217 for Alzheimer's Disease in a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background Phospho‐tau217 (p‐tau217) has emerged as a leading blood‐based biomarker for Alzheimer's disease (AD) and has been recommended by an Alzheimer's Association Workgroup as a biomarker for AD pathology. However, its translational performance in clinical settings remains to be explored.
Sehrawat A, Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Berman S, Sweet R, Ikonomovic M, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Exploring Racial Differences in the Association of Plasma Biomarkers and APOE4 Genotype in a Large Memory Clinic Cohort [PDF]

Alzheimers Dement
Abstract Background The APOE4 is a major genetic risk factor for Alzheimer's disease (AD) and has been shown to impact plasma AD biomarker levels. We utilized a large memory clinic cohort to assess potential differences in this association race.
Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +25 more
europepmc   +2 more sources

Alzheimer's disease plasma biomarkers are differentially affected by Type II Diabetes Mellitus based on those with Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Type II Diabetes Mellitus (T2DM) remains one of the strongest comorbidities associated with the development of AD. Use of fluid‐based biomarker assays allows for quick, inexpensive, and accurate identification of those at high risk for developing AD or likely already have the disease.
Grizzanti J, Zeng X, Deek R, Nafash M, Gu J, Choity L, Lafferty T, Farinas M, Bedison M, Mercurio R, Matan C, Gogola A, Kofler J, Tudorascu D, Shaaban C, Lingler J, Pascoal T, Klunk W, Villemagne V, Ikonomovic M, Berman S, Sweet R, Snitz B, Cohen A, Kamboh M, Lopez O, Karikari T.   +26 more
europepmc   +2 more sources

EFECTOS ECOTÓXICOS DE METALES PESADOS SOBRE Daphnia magna Y Paracheirodon innesi EN UN RÍO DE LA AMAZONÍA PERUANA

Acta Biológica Colombiana, 2023
El río Madre de Dios, en la Amazonía del Perú, es un cuerpo de agua que recibe relaves y desechos con mercurio (Hg) vertidos por la minería aurífera artesanal, informal e ilegal.
Esther Méniz-Oshiro, José Alberto Iannacone Olíver   +1 more
doaj   +1 more source

Uma revisão de escopo de revisões sistemáticas sobre exposição humana ao mercúrio

Revista Brasileira de Saúde Ocupacional, 2022
Resumo: Introdução: a promulgação da Convenção de Minamata no Brasil em 2018 incentivou o cumprimento dos seus objetivos em reduzir o uso e a poluição por mercúrio.
Luciana Azevedo de Sousa, Maria Paula do Amaral Zaitune   +1 more
doaj   +1 more source

ORCHESTRATING DIFFERENCE AND SIMILARITY: Black Fungibility, and the Spatial Redrawing of Racial Categories in Spanish Colonial Morocco, Sahara and Guinea

International Journal of Urban and Regional Research, EarlyView.
Abstract In this article I dissect the spatial strategies through which the Spanish attempted to orchestrate both racial difference and similarity in the African colonies of Morocco, Western Sahara and Equatorial Guinea during the first half of the twentieth century.
Pol Fité Matamoros
wiley   +1 more source

Irregularidad menstrual y exposición a mercurio en la minería artesanal del oro en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. El proceso de extracción del oro por amalgamación con mercurio es común en la minería artesanal. Los efectos sobre la reproducción de la exposición al mercurio elemental en el contexto de la minería del oro, no han sido suficientemente ...
Laura Andrea Rodríguez-Villamizar, Diana Carolina Jaimes, Adelaida Manquián-Tejos, Luz Helena Sánchez   +3 more
doaj   +1 more source